Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Takashima, S.; Tsuji, S.; Tsujimoto, M.
    Comparison of the enzymatic properties of mouse beta-galactoside alpha2,6-sialyltransferases, ST6Gal I and II (2003), J. Biochem., 134, 287-296.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.3.1 expression in COS-7 cells Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.3.1 1.25
-
 beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.3.1 60122
-
 x * 60122, calculation from nucleotide sequence Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.3.1 additional information Mus musculus the enzyme is responsible for the synthesis of 6'-sialylolifosaccharides in milk ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.1 Mus musculus
-
 ST6Gal I
-
2.4.3.1 Mus musculus
-
 ST6Gal II
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.1 brain
-
 Mus musculus
-
2.4.3.1 brain of 11-, 15- and 17-day embryos Mus musculus
-
2.4.3.1 embryo 11-day, 15-day or 17-day Mus musculus
-
2.4.3.1 embryo brain of 11-, 15- and 17-day old embryos Mus musculus
-
2.4.3.1 heart
-
 Mus musculus
-
2.4.3.1 kidney
-
 Mus musculus
-
2.4.3.1 liver
-
 Mus musculus
-
2.4.3.1 lung
-
 Mus musculus
-
2.4.3.1 lung very low expression Mus musculus
-
2.4.3.1 mammary gland lactating Mus musculus
-
2.4.3.1 additional information ubiquitously expressed Mus musculus
-
2.4.3.1 oviduct of pregnant mouse Mus musculus
-
2.4.3.1 skeletal muscle
-
 Mus musculus
-
2.4.3.1 skeletal muscle very low expression Mus musculus
-
2.4.3.1 spleen
-
 Mus musculus
-
2.4.3.1 spleen very low expression Mus musculus
-
2.4.3.1 testis
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.1 CMP-N-acetylneuraminate + alpha1-acid glycoprotein 20.6% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine Mus musculus CMP + ?
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + asialo-alpha1-acid glycoprotein 12.3% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine Mus musculus CMP + ?
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + asialo-alpha1-acid glycoprotein 176% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine Mus musculus CMP + alpha1-acid glycoprotein
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + asialo-fetuin 106% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine Mus musculus CMP + fetuin
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + asialo-fetuin 21% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine Mus musculus CMP + fetuin
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + asialoovomucoid 9.1% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine Mus musculus CMP + ?
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-1,3-galactosyl-beta-1,4-D-glucose 106% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine Mus musculus CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-1,3-galactosyl-beta-1,4-D-glucose
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-1,3-galactosyl-beta-1,4-D-glucose 129% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine Mus musculus CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosaminyl-1,3-galactosyl-beta-1,4-D-glucose
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
 Mus musculus CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + lacto-N-tetraose 36.8% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine Mus musculus CMP + ?
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + lactose 15.5% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine Mus musculus CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-beta-D-glucose
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + ovomucoid 8.4% of the activity with beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine Mus musculus CMP + ?
-
 ?
2.4.3.1 additional information the enzyme is responsible for the synthesis of 6'-sialylolifosaccharides in milk Mus musculus ?
-
 ?
2.4.3.1 additional information ST6Gal II shows no activity towards oligosaccharides such as Galbeta1,3GalNAc, Galbeta1,3GlcNAc, lactose, and lacto-N-tetraose, which do not have the Galbeta1,4GlcNAc structure at the nonreducing end of their carbohydrate groups. Relatively low activity towards some glycoproteins, which are considered to have the Galbeta1,4GlcNAc structure at the nonreducing end of the carbohydrate groups Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.3.1 ? x * 60122, calculation from nucleotide sequence Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.4.3.1 beta-galactoside alpha2,6-sialyltransferase ST6Gal II
-
 Mus musculus
2.4.3.1 ST6Gal I
-
 Mus musculus
2.4.3.1 ST6Gal II
-
 Mus musculus