Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Shepherdley, C.A.; Richardson, S.J.; Evans, B.K.; Kuehn, E.R.; Darras, V.M.
    Characterization of outer ring iodothyronine deiodinases in tissues of the saltwater crocodile (Crocodylus porosus) (2002), Gen. Comp. Endocrinol., 125, 387-398.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.21.99.4 dithiothreitol 10 mM required Crocodylus porosus
1.21.99.4 dithiothreitol type II-like enzyme from liver microsomes: 15 mM required. Type II-like enzyme from gut and kidney microsomes: 20 mM required Crocodylus porosus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.4 additional information no inhibition by propylthiouracil, type II-like enzyme Crocodylus porosus
1.21.99.4 propylthiouracil
-
 Crocodylus porosus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.21.99.4 additional information
-
 additional information
-
 Crocodylus porosus
1.21.99.4 0.00256
-
 3,3',5-triiodothyronine type I-like activity in kidney microsomes Crocodylus porosus
1.21.99.4 0.005
-
 3,3',5-triiodothyronine type I-like activity in liver microsomes Crocodylus porosus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.21.99.4 microsome
-
 Crocodylus porosus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.4 Crocodylus porosus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.4 gut low type I-like activity, type II-like activity is the predominant activity Crocodylus porosus
-
1.21.99.4 gut type II-like activity is the predominant activity Crocodylus porosus
-
1.21.99.4 kidney type I-like activity Crocodylus porosus
-
1.21.99.4 liver low type II-like activity, type I-like activity is the predominant activity Crocodylus porosus
-
1.21.99.4 liver type I-like activity is the predominant activity Crocodylus porosus
-
1.21.99.4 additional information no type-II-like activity in kidney Crocodylus porosus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.4 3,3',5-triiodothyronine + AH2 rT3 ORD activity Crocodylus porosus 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 L-thyroxine + AH2 outer ring iodothyronine deiodinase activity, T4 ORD activity Crocodylus porosus 3,3',5-triiodothyronine + iodide + A + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.99.4 type I-like deiodinase
-
 Crocodylus porosus
1.21.99.4 type II-like deiodinase
-
 Crocodylus porosus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.21.99.4 25 30 T4 ORD activity of type II-like enzyme from gut and kidney microsomes Crocodylus porosus
1.21.99.4 30 35 rT3 ORD activity of type I-like enzýme Crocodylus porosus
1.21.99.4 30 35 T4 ORD activity of type II-like enzyme from liver microsomes Crocodylus porosus