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Literature summary extracted from

  • Kuiper, G.G.; Wassen, F.; Klootwijk, W.; Van Toor, H.; Kaptein, E.; Visser, T.J.
    Molecular basis for the substrate selectivity of cat type I iodothyronine deiodinase (2003), Endocrinology, 144, 5411-5421.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.21.99.4 expression in COS cells Felis catus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.4 propylthiouracil native and recombinant enzyme, IC50: 0.005-0.01 mM Felis catus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.21.99.4 0.0007
-
 sulfated reverse triiodothyronine wild-type enzyme Felis catus
1.21.99.4 0.015
-
 reverse triiodothyronine wild-type enzyme Felis catus

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.4 Felis catus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.4 reverse triiodothyronine + AH2
-
 Felis catus diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 sulfated reverse triiodothyronine + AH2
-
 Felis catus diiodothyronine + iodide + A + H+ + ?
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.21.99.4 0.005 0.01 native and recombinant enzyme, IC50: 0.005-0.01 mM Felis catus propylthiouracil