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Literature summary extracted from

  • Winter, H.R.; Unadkat, J.D.
    Identification of cytochrome P450 and arylamine N-acetyltransferase isoforms involved in sulfadiazine metabolism (2005), Drug Metab. Dispos., 33, 969-976.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.5 expression in Escherichia coli Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.5 3.1
-
 Sulfadiazine
-
 Homo sapiens
2.3.1.118 3.1
-
 Sulfadiazine native enzyme, pH 7.5 Homo sapiens
2.3.1.118 5.4
-
 Sulfadiazine recombinant isoform NAT2*4, pH 7.5 Homo sapiens
2.3.1.118 5.8
-
 Sulfadiazine recombinant isoform NAT1*3, pH 7.5 Homo sapiens
2.3.1.118 136
-
 sulfamethazine recombinant isoform NAT2*4, pH 7.5 Homo sapiens
2.3.1.118 687
-
 p-Aminobenzoic acid recombinant isoform NAT1*3, pH 7.5 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.118 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.5 Homo sapiens
-
-
-
2.3.1.118 Homo sapiens
-
 expression of isiforms NAT1*3 and NAT2*4 in Escherichia coli
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.5 liver
-
 Homo sapiens
-
2.3.1.118 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.118 0.0008
-
 substrate sulfamethazine, recombinant isoform NAT2*4, pH 7.5 Homo sapiens
2.3.1.118 0.0029
-
 substrate sulfadiazine, recombinant isoform NAT2*4, pH 7.5 Homo sapiens
2.3.1.118 0.0064
-
 substrate p-aminobenzoic aicd, recombinant isoform NAT1*3, pH 7.5 Homo sapiens
2.3.1.118 0.0183
-
 substrate sulfadiazine, recombinant isoform NAT1*3, pH 7.5 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.5 acetyl-CoA + sulfadiazine
-
 Homo sapiens CoA + N-acetylsulfadiazine
-
 ?
2.3.1.118 p-aminobenzoic acid + acetyl-CoA
-
 Homo sapiens N-acetyl-p-aminobenzoic acid + CoA
-
 ?
2.3.1.118 sulfadiazine + acetyl-CoA
-
 Homo sapiens N-acetyl-sulfadiazine + CoA
-
 ?
2.3.1.118 sulfamethazine + acetyl-CoA
-
 Homo sapiens N-acetyl-sulfamethazine + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.5 arylamine N-acetyltransferase 2
-
 Homo sapiens
2.3.1.5 NAT2
-
 Homo sapiens
2.3.1.118 N-arylamine acetyltransferase
-
 Homo sapiens