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Literature summary extracted from

  • Johansson, M.
    Identification of a novel human uridine phosphorylase (2003), Biochem. Biophys. Res. Commun., 307, 41-46.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.3 expression in Escherichia coli as a fusion protein to glutathione-S-transferase Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.3 0.024
-
 5-fluorouridine pH 7.4, 37°C Homo sapiens
2.4.2.3 0.073
-
 thymidine pH 7.4, 37°C Homo sapiens
2.4.2.3 0.076
-
 uridine pH 7.4, 37°C Homo sapiens
2.4.2.3 0.3
-
 deoxyuridine pH 7.4, 37°C Homo sapiens
2.4.2.3 0.427
-
 5-fluoro-2'-deoxyuridine pH 7.4, 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.3 Homo sapiens O95045
-
-
2.4.2.3 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.3 kidney Upase-2 is predominantly expressed in Homo sapiens
-
2.4.2.3 liver Upase-2 is predominantly expressed in Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.3 5-fluoro-2'-deoxyuridine + phosphate
-
 Homo sapiens 5-fluorouracil + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?
2.4.2.3 5-fluorouridine + phosphate
-
 Homo sapiens 5-fluorouracil + alpha-D-ribose-1-phosphate
-
 ?
2.4.2.3 deoxyuridine + phosphate
-
 Homo sapiens uracil + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?
2.4.2.3 thymidine + phosphate
-
 Homo sapiens thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?
2.4.2.3 uridine + phosphate
-
 Homo sapiens uracil + alpha-D-ribose 1-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.3 UPase-2
-
 Mus musculus
2.4.2.3 UPase-2
-
 Homo sapiens
2.4.2.3 uridine phosphorylase-2
-
 Mus musculus
2.4.2.3 uridine phosphorylase-2
-
 Homo sapiens