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Literature summary extracted from
- The enzymes, regulation, and genetics of bile acid synthesis (2003), Annu. Rev. Biochem., 72, 137-174.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.2.27 | PPARII | peroxisomal proliferator activated receptor-II activates the enzyme, fibrates are antagonizing the receptor activity | Mus musculus |  |
| 3.1.2.27 | PPARII | peroxisomal proliferator activated receptor-II activates the enzyme, fibrates are antagonizing the receptor activity | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.29 | endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| 1.14.14.29 | endoplasmic reticulum | - |
Mus musculus | 5783 | - |
| 3.1.2.27 | peroxisome | - |
Mus musculus | 5777 | - |
| 3.1.2.27 | peroxisome | - |
Homo sapiens | 5777 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.29 | 58255 | - |
x * 58255, calculation from nucleotide sequence | Homo sapiens |
| 1.14.14.29 | 58255 | - |
x * 58255, calculation from nucleotide sequence | Mus musculus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.29 | cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 | Mus musculus | CYP7B1 oxysterol 7alpha-hydroxylase pathway synthesizes 25% to 30% of all bile acids | cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O | - |
? | |
| 1.14.14.29 | cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 | Mus musculus | CYP7B1 oxysterol 7alpha-hydroxylase pathway synthesizes 25% to 30% of all bile acids | cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O | - |
? | |
| 3.1.2.27 | choloyl-CoA + H2O | Mus musculus | enzyme is involved in the regulation of free to conjugated bile acid ratio, overview | cholate + CoA | - |
? | |
| 3.1.2.27 | choloyl-CoA + H2O | Homo sapiens | enzyme is involved in the regulation of free to conjugated bile acid ratio, overview | cholate + CoA | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.29 | Homo sapiens | O75881 | - |
- |
| 1.14.14.29 | Mus musculus | Q60991 | - |
- |
| 1.14.14.57 | Homo sapiens | - |
- |
- |
| 3.1.2.27 | Homo sapiens | - |
- |
- |
| 3.1.2.27 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.29 | liver | hepatic expression is induced during the third week of life and thereafter exhibits a sexually dimorphic expression pattern in this and other tissues in which expression is higher in the male | Mus musculus | - |
| 3.1.2.27 | brain | - |
Mus musculus | - |
| 3.1.2.27 | brain | - |
Homo sapiens | - |
| 3.1.2.27 | liver | - |
Mus musculus | - |
| 3.1.2.27 | liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.29 | cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 | - |
Homo sapiens | cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O | - |
? | |
| 1.14.14.29 | cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 | - |
Mus musculus | cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O | - |
? | |
| 1.14.14.29 | cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 | CYP7B1 oxysterol 7alpha-hydroxylase pathway synthesizes 25% to 30% of all bile acids | Mus musculus | cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O | - |
? | |
| 1.14.14.29 | cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 | - |
Homo sapiens | cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O | - |
? | |
| 1.14.14.29 | cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 | - |
Mus musculus | cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O | - |
? | |
| 1.14.14.29 | cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 | CYP7B1 oxysterol 7alpha-hydroxylase pathway synthesizes 25% to 30% of all bile acids | Mus musculus | cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O | - |
? | |
| 3.1.2.27 | choloyl-CoA + H2O | - |
Mus musculus | cholate + CoA | - |
? | |
| 3.1.2.27 | choloyl-CoA + H2O | - |
Homo sapiens | cholate + CoA | - |
? | |
| 3.1.2.27 | choloyl-CoA + H2O | enzyme is involved in the regulation of free to conjugated bile acid ratio, overview | Mus musculus | cholate + CoA | - |
? | |
| 3.1.2.27 | choloyl-CoA + H2O | enzyme is involved in the regulation of free to conjugated bile acid ratio, overview | Homo sapiens | cholate + CoA | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.14.29 | ? | x * 58255, calculation from nucleotide sequence | Homo sapiens |
| 1.14.14.29 | ? | x * 58255, calculation from nucleotide sequence | Mus musculus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.57 | CYP3A4 | - |
Homo sapiens |
| 3.1.2.27 | coenzyme A thioesterase 2 | - |
Mus musculus |
| 3.1.2.27 | coenzyme A thioesterase 2 | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.29 | cytochrome P-450 | - |
Homo sapiens | |
| 1.14.14.29 | cytochrome P-450 | - |
Mus musculus | |
| 1.14.14.29 | NADPH | - |
Homo sapiens | |
| 1.14.14.29 | NADPH | - |
Mus musculus | |
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