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Literature summary extracted from

  • Feng, J.; Lindahl, P.A.
    Effect of sodium sulfide on Ni-containing carbon monoxide dehydrogenases (2004), J. Am. Chem. Soc., 126, 9094-9100.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.7.4 Sulfide partial Moorella thermoacetica
1.2.7.4 Sulfide partial Rhodospirillum rubrum

Organism

EC Number Organism UniProt Comment Textmining
1.2.7.4 Moorella thermoacetica
-
-
-
1.2.7.4 Rhodospirillum rubrum
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.2.7.4 CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+ mechanism, CO binding labilizes the hydroxyl bridging Ni and Fe and increases the nucleophilic tendency toward attacking Ni-bound carbonyl Moorella thermoacetica
a
1.2.7.4 CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+ mechanism, CO binding labilizes the hydroxyl bridging Ni and Fe and increases the nucleophilic tendency toward attacking Ni-bound carbonyl Rhodospirillum rubrum
a

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.7.4 0.00004
-
 Sulfide pH 7.5, 30°C Rhodospirillum rubrum
1.2.7.4 0.00006
-
 Sulfide pH 7.5, 30°C Moorella thermoacetica