Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Schipper, L.; Spee, B.; Rothuizen, J.; Woutersen-van Nijnanten, F.; Fink-Gremmels, J.
    Characterisation of 11beta-hydroxysteroid dehydrogenases in feline kidney and liver (2004), Biochim. Biophys. Acta, 1688, 68-77.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.B40 0.0002
-
 cortisol pH 7.4, 37°C Felis catus
1.1.1.146 0.0008
-
 cortisone kidney enzyme, pH 7.4, 37°C Felis catus
1.1.1.146 0.002
-
 cortisol kidney enzyme, pH 7.4, 37°C Felis catus
1.1.1.146 0.01
-
 cortisone liver enzyme, pH 7.4, 37°C Felis catus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.B40 endoplasmic reticulum
-
 Felis catus 5783
-
1.1.1.146 endoplasmic reticulum
-
 Felis catus 5783
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 cortisol + NAD+ Felis catus
-
 cortisone + NADH
-
 ir
1.1.1.146 cortisone + NADPH + H+ Felis catus liver, kidney 11beta-HSD1 cortisol + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Felis catus
-
-
-
1.1.1.146 Felis catus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.B40
-
 Felis catus
1.1.1.146
-
 Felis catus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 kidney
-
 Felis catus
-
1.1.1.146 kidney
-
 Felis catus
-
1.1.1.146 liver
-
 Felis catus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 cortisol + NAD+
-
 Felis catus cortisone + NADH
-
 ir
1.1.1.146 cortisone + NADPH + H+ liver, kidney 11beta-HSD1 Felis catus cortisol + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11beta-HSD2
-
 Felis catus
1.1.1.B40 11beta-hydroxysteroid dehydrogenases type 2
-
 Felis catus
1.1.1.146 11beta-HSD1
-
 Felis catus
1.1.1.146 11beta-hydroxysteroid dehydrogenases type 1
-
 Felis catus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.B40 37
-
 assay at Felis catus
1.1.1.146 37
-
 assay at Felis catus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.B40 7.4
-
 assay at Felis catus
1.1.1.146 7.4
-
 assay at Felis catus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B40 NAD+
-
 Felis catus
1.1.1.146 NADP+
-
 Felis catus
1.1.1.146 NADPH
-
 Felis catus