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Literature summary extracted from

  • Ribeiro, J.M.; Carloto, A.; Costas, M.J.; Cameselle, J.C.
    Human placenta hydrolases active on free ADP-ribose: an ADP-sugar pyrophosphatase and a specific ADP-ribose pyrophosphatase (2001), Biochim. Biophys. Acta, 1526, 86-94.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.13 F-
-
 Homo sapiens
3.6.1.13 N-acetyl-p-benzoquinoneimine
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.13 0.0004
-
 ADPribose pH 7.5, 37°C Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.13 Mg2+ maximal activity at 2 mM, Mg2+ or Mn2+ required Homo sapiens
3.6.1.13 Mn2+ maximal activity at 0.02-0.05 mM with a steep decrease at increasing pH-values, Mg2+ or Mn2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.13 ADP-ribose + H2O Homo sapiens the enzyme may have a predominant role in free ADP-ribose turnover and as a protective agent preventing the accumulation of this potential dangerous metabolite AMP + D-ribose 5-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.13 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.13
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.13 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.13 ADP-ribose + H2O
-
 Homo sapiens AMP + D-ribose 5-phosphate
-
 ?
3.6.1.13 ADP-ribose + H2O the enzyme may have a predominant role in free ADP-ribose turnover and as a protective agent preventing the accumulation of this potential dangerous metabolite Homo sapiens AMP + D-ribose 5-phosphate
-
 ?
3.6.1.13 IDP-ribose + H2O 138% of the activity with ADPribose Homo sapiens IMP + D-ribose 5-phosphate
-
 ?
3.6.1.13 additional information no activity with ADPglucose, ADPmannose, UDPglucose Homo sapiens ?
-
 ?

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.6.1.13 7 9 linearly decreasing activity profile from pH 7 to pH 9, with activity at pH 9 being 50% of that at pH 7 Homo sapiens