EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.40 | acetyl carnitine | 19% activation at 5 mM | Ricinus communis | |
1.1.1.40 | acetyl-CoA | 24% activation at 0.005 mM | Ricinus communis | |
1.1.1.40 | ATP | 18% activation at 5 mM | Ricinus communis | |
1.1.1.40 | citrate | 22% activation at 5 mM | Ricinus communis | |
1.1.1.40 | CoA | 29% activation at 0.005 mM | Ricinus communis | |
1.1.1.40 | L-glutamate | 15% activation at 5 mM | Ricinus communis | |
1.1.1.40 | malonyl-CoA | 15% activation at 0.005 mM | Ricinus communis | |
1.1.1.40 | palmitoyl-CoA | 69% activation at 0.005 mM | Ricinus communis | |
1.1.1.40 | succinate | 65% activation at 5 mM | Ricinus communis | |
1.1.1.40 | UDP | 10% activation at 5 mM | Ricinus communis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.40 | AMP | 41% inhibition at 5 mM | Ricinus communis | |
1.1.1.40 | cAMP | 10% inhibition at 5 mM | Ricinus communis | |
1.1.1.40 | CO2 | product inhibition, uncompetitive with respect to L-malate and NADP+, 39% inhibition at 25 mM | Ricinus communis | |
1.1.1.40 | D-fructose-1,6-bisphosphate | 13% inhibition at 5 mM | Ricinus communis | |
1.1.1.40 | GDP | 13% inhibition at 5 mM | Ricinus communis | |
1.1.1.40 | NADPH | product inhibition, competitive with respect to L-malate and NADP+ | Ricinus communis | |
1.1.1.40 | oxalate | 51% inhibition at 1 mM | Ricinus communis | |
1.1.1.40 | phosphoenolpyruvate | 39% inhibition at 5 mM | Ricinus communis | |
1.1.1.40 | pyruvate | product inhibition, competitive with respect to L-malate, 16% inhibition at 5 mM | Ricinus communis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.40 | 0.0103 | - |
NADP+ | pH 7.6-7.7, 25°C | Ricinus communis | |
1.1.1.40 | 0.22 | - |
L-malate | pH 7.6-7.7, 25°C | Ricinus communis |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.1.1.40 | leucoplast | - |
Ricinus communis | 9516 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.40 | Mg2+ | enzyme requires either Mg2+ or Mn2+ for activity, no activity without divalent cation | Ricinus communis | |
1.1.1.40 | Mn2+ | enzyme requires either Mg2+ or Mn2+ for activity, no activity without divalent cation | Ricinus communis |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.1.1.40 | 63000 | - |
4 * 63000, approximately, SDS-PAGE | Ricinus communis |
1.1.1.40 | 254000 | - |
gel filtration | Ricinus communis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.40 | (S)-malate + NADP+ | Ricinus communis | enzyme is involved in fatty acid biosynthesis in oil seed leucoplasts, overview | pyruvate + CO2 + NADPH | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.40 | Ricinus communis | - |
cv. Baker 296 | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.40 | 5160fold from oil seed | Ricinus communis |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.40 | endosperm | developing, maximal at stage 7 of endosperm development, overview | Ricinus communis | - |
1.1.1.40 | seed | - |
Ricinus communis | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.1.1.40 | 18.2 | - |
purified enzyme | Ricinus communis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.40 | (S)-malate + NADP+ | enzyme is involved in fatty acid biosynthesis in oil seed leucoplasts, overview | Ricinus communis | pyruvate + CO2 + NADPH | - |
r | |
1.1.1.40 | (S)-malate + NADP+ | decarboxylation is favoured | Ricinus communis | pyruvate + CO2 + NADPH | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.40 | tetramer | 4 * 63000, approximately, SDS-PAGE | Ricinus communis |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.40 | NADP-dependent malic enzyme | - |
Ricinus communis |
1.1.1.40 | NADP-ME | - |
Ricinus communis |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.40 | 25 | - |
assay at, both reaction directions | Ricinus communis |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.40 | 44 | - |
stable for at least 10 min | Ricinus communis |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.40 | 7.6 | 7.7 | both reaction directions | Ricinus communis |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.40 | 7 | 8.2 | broad range, 80% of maximal activity at pH 7.0 and pH 8.2 | Ricinus communis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.40 | NADP+ | absolutely specific for, no activity with NAD+ | Ricinus communis | |
1.1.1.40 | NADPH | - |
Ricinus communis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.40 | additional information | - |
additional information | inhibition kinetics | Ricinus communis | |
1.1.1.40 | 0.016 | - |
pyruvate | pH 7.6-7.7, 25°C | Ricinus communis | |
1.1.1.40 | 0.046 | - |
NADPH | versus NADP+, pH 7.6-7.7, 25°C | Ricinus communis | |
1.1.1.40 | 0.372 | - |
CO2 | versus NADP+, pH 7.6-7.7, 25°C | Ricinus communis | |
1.1.1.40 | 0.492 | - |
NADPH | versus L-malate, pH 7.6-7.7, 25°C | Ricinus communis | |
1.1.1.40 | 0.83 | - |
CO2 | versus L-malate, pH 7.6-7.7, 25°C | Ricinus communis |