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Literature summary extracted from
- New insights into the ATP-dependent Clp protease: Escherichia coli and beyond (1999), Mol. Microbiol., 32, 449-458.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.21.92 | Clp sequenced | Pseudomonas aeruginosa |
| 3.4.21.92 | Clp sequenced | Rhodobacter capsulatus |
| 3.4.21.92 | Clp sequenced | Enterococcus faecalis |
| 3.4.21.92 | Clp sequenced | Streptococcus pyogenes |
| 3.4.21.92 | Clp sequenced | Myxococcus xanthus |
| 3.4.21.92 | Clp sequenced | Streptomyces coelicolor |
| 3.4.21.92 | Clp sequenced | Helicobacter pylori |
| 3.4.21.92 | Clp sequenced | Synechococcus sp. |
| 3.4.21.92 | Clp sequenced | Clostridium acetobutylicum |
| 3.4.21.92 | Clp sequenced | Porphyromonas gingivalis |
| 3.4.21.92 | Clp sequenced | Bordetella pertussis |
| 3.4.21.92 | Clp sequenced | Deinococcus radiodurans |
| 3.4.21.92 | Clp sequenced | Listeria monocytogenes |
| 3.4.21.92 | Clp sequenced | Chlorobaculum tepidum |
| 3.4.21.92 | Clp sequenced | Shewanella putrefaciens |
| 3.4.21.92 | Clp sequenced | Chlamydomonas reinhardtii |
| 3.4.21.92 | Clp sequenced | Chlorella vulgaris |
| 3.4.21.92 | Clp sequenced | Epifagus virginiana |
| 3.4.21.92 | Clp sequenced | Haemophilus influenzae |
| 3.4.21.92 | Clp sequenced | Lactococcus lactis |
| 3.4.21.92 | Clp sequenced | Marchantia polymorpha |
| 3.4.21.92 | Clp sequenced | Bacillus subtilis |
| 3.4.21.92 | Clp sequenced | Nicotiana tabacum |
| 3.4.21.92 | Clp sequenced | Oryza sativa |
| 3.4.21.92 | Clp sequenced | Paracoccus denitrificans |
| 3.4.21.92 | Clp sequenced | Pinus contorta |
| 3.4.21.92 | Clp sequenced | Pinus thunbergii |
| 3.4.21.92 | Clp sequenced | Streptococcus salivarius |
| 3.4.21.92 | Clp sequenced | Borreliella burgdorferi |
| 3.4.21.92 | Clp sequenced | Treponema pallidum |
| 3.4.21.92 | Clp sequenced | Triticum aestivum |
| 3.4.21.92 | Clp sequenced | Yersinia enterocolitica |
| 3.4.21.92 | Clp sequenced | Zea mays |
| 3.4.21.92 | Clp sequenced | Caulobacter vibrioides |
| 3.4.21.92 | Clp sequenced | Chlamydia trachomatis |
| 3.4.21.92 | Clp sequenced | Chlamydomonas moewusii |
| 3.4.21.92 | Clp sequenced | Aquifex aeolicus |
| 3.4.21.92 | Clp sequenced, nuclear encoded gene | Arabidopsis thaliana |
| 3.4.21.92 | Clp sequenced, nuclear encoded gene | Populus tremula |
| 3.4.21.92 | Clp sequenced, nuclear encoded gene | Fritillaria agrestis |
| 3.4.21.92 | Clp sequenced, nuclear encoded gene | Homo sapiens |
| 3.4.21.92 | Clp sequenced, nuclear encoded gene | Solanum lycopersicum |
| 3.4.21.92 | Clp sequenced, nuclear encoded gene | Mus musculus |
| 3.4.21.92 | Clp sequenced, nuclear encoded gene | Caenorhabditis elegans |
| 3.4.21.92 | Clp sequenced, plastid encoded gene | Cyanophora paradoxa |
| 3.4.21.92 | clpP gene detected | Salmonella enterica subsp. enterica serovar Typhimurium |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 3.4.21.92 | - |
Escherichia coli |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.92 | mitochondrion | - |
Populus tremula | 5739 | - |
| 3.4.21.92 | mitochondrion | - |
Homo sapiens | 5739 | - |
| 3.4.21.92 | mitochondrion | - |
Mus musculus | 5739 | - |
| 3.4.21.92 | mitochondrion | - |
Caenorhabditis elegans | 5739 | - |
| 3.4.21.92 | plastid | - |
Chlorella vulgaris | 9536 | - |
| 3.4.21.92 | plastid | - |
Epifagus virginiana | 9536 | - |
| 3.4.21.92 | plastid | - |
Fritillaria agrestis | 9536 | - |
| 3.4.21.92 | plastid | - |
Solanum lycopersicum | 9536 | - |
| 3.4.21.92 | plastid | - |
Marchantia polymorpha | 9536 | - |
| 3.4.21.92 | plastid | - |
Nicotiana tabacum | 9536 | - |
| 3.4.21.92 | plastid | - |
Oryza sativa | 9536 | - |
| 3.4.21.92 | plastid | - |
Pinus contorta | 9536 | - |
| 3.4.21.92 | plastid | - |
Pinus thunbergii | 9536 | - |
| 3.4.21.92 | plastid | - |
Triticum aestivum | 9536 | - |
| 3.4.21.92 | plastid | - |
Zea mays | 9536 | - |
| 3.4.21.92 | plastid | - |
Chlamydomonas moewusii | 9536 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.92 | Mg2+ | ClpA degrades large proteins down to short peptides of 7 to 10 amino acids, the process requires both Mg2+ and ATP hydrolysis | Escherichia coli |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.92 | additional information | Bacillus subtilis | ClpP linked to many activities, including sporulation, cell competence, stress tolerance and regulation of gene expression | ? | - |
? | |
| 3.4.21.92 | additional information | Escherichia coli | removing of irreversibly damaged polypeptides | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.92 | Aquifex aeolicus | O67357 | - |
- |
| 3.4.21.92 | Arabidopsis thaliana | P56772 | - |
- |
| 3.4.21.92 | Arabidopsis thaliana | Q787X4 | - |
- |
| 3.4.21.92 | Bacillus subtilis | P80244 | - |
- |
| 3.4.21.92 | Bordetella pertussis | - |
- |
- |
| 3.4.21.92 | Borreliella burgdorferi | O51698 | - |
- |
| 3.4.21.92 | Caenorhabditis elegans | Q27539 | - |
- |
| 3.4.21.92 | Caulobacter vibrioides | B8GX16 | - |
- |
| 3.4.21.92 | Chlamydia trachomatis | P38002 | - |
- |
| 3.4.21.92 | Chlamydomonas moewusii | P42379 | - |
- |
| 3.4.21.92 | Chlamydomonas reinhardtii | P42380 | - |
- |
| 3.4.21.92 | Chlorella vulgaris | P56317 | - |
- |
| 3.4.21.92 | Chlorobaculum tepidum | - |
- |
- |
| 3.4.21.92 | Clostridium acetobutylicum | - |
- |
- |
| 3.4.21.92 | Cyanophora paradoxa | Q36863 | - |
- |
| 3.4.21.92 | Deinococcus radiodurans | - |
- |
- |
| 3.4.21.92 | Enterococcus faecalis | - |
- |
- |
| 3.4.21.92 | Epifagus virginiana | P30063 | - |
- |
| 3.4.21.92 | Escherichia coli | - |
- |
- |
| 3.4.21.92 | Fritillaria agrestis | O49081 | - |
- |
| 3.4.21.92 | Haemophilus influenzae | P43867 | - |
- |
| 3.4.21.92 | Helicobacter pylori | - |
- |
- |
| 3.4.21.92 | Homo sapiens | Q16740 | - |
- |
| 3.4.21.92 | Lactococcus lactis | Q9ZAB0 | - |
- |
| 3.4.21.92 | Listeria monocytogenes | - |
- |
- |
| 3.4.21.92 | Marchantia polymorpha | P12208 | - |
- |
| 3.4.21.92 | Mus musculus | O88696 | - |
- |
| 3.4.21.92 | Mycobacterium tuberculosis | P9WPC5 and P9WPC3 | - |
- |
| 3.4.21.92 | Mycobacterium tuberculosis H37Rv | P9WPC5 and P9WPC3 | - |
- |
| 3.4.21.92 | Myxococcus xanthus | - |
- |
- |
| 3.4.21.92 | Nicotiana tabacum | P12210 | tobacco | - |
| 3.4.21.92 | Oryza sativa | P0C312 | rice | - |
| 3.4.21.92 | Paracoccus denitrificans | P54414 | - |
- |
| 3.4.21.92 | Pinus contorta | P36387 | - |
- |
| 3.4.21.92 | Pinus thunbergii | P41609 | - |
- |
| 3.4.21.92 | Populus tremula | - |
x tremuloides | - |
| 3.4.21.92 | Porphyromonas gingivalis | - |
- |
- |
| 3.4.21.92 | Pseudomonas aeruginosa | - |
- |
- |
| 3.4.21.92 | Rhodobacter capsulatus | - |
- |
- |
| 3.4.21.92 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
| 3.4.21.92 | Shewanella putrefaciens | - |
- |
- |
| 3.4.21.92 | Solanum lycopersicum | Q42886 | - |
- |
| 3.4.21.92 | Streptococcus pyogenes | - |
- |
- |
| 3.4.21.92 | Streptococcus salivarius | P36398 | - |
- |
| 3.4.21.92 | Streptomyces coelicolor | - |
- |
- |
| 3.4.21.92 | Synechococcus sp. | - |
strain PCC 7942-3 | - |
| 3.4.21.92 | Synechococcus sp. | O34125 | strain PCC 7942-2 | - |
| 3.4.21.92 | Synechococcus sp. | P54415 | strain PCC 7942-1 | - |
| 3.4.21.92 | Synechocystis sp. | P54416 | strain PCC 6803-1 | - |
| 3.4.21.92 | Synechocystis sp. | P74467 | strain PCC 6803-3 | - |
| 3.4.21.92 | Synechocystis sp. | Q59993 | strain PCC 6803-2 | - |
| 3.4.21.92 | Treponema pallidum | O84003 | - |
- |
| 3.4.21.92 | Triticum aestivum | P24064 | - |
- |
| 3.4.21.92 | Yersinia enterocolitica | O30612 | - |
- |
| 3.4.21.92 | Yersinia enterocolitica | Q60107 | - |
- |
| 3.4.21.92 | Zea mays | P12340 | corn, maize | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.92 | additional information | ClpP linked to many activities, including sporulation, cell competence, stress tolerance and regulation of gene expression | Bacillus subtilis | ? | - |
? | |
| 3.4.21.92 | additional information | removing of irreversibly damaged polypeptides | Escherichia coli | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.92 | Clp protease | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
| 3.4.21.92 | Clp protease | - |
Escherichia coli |
| 3.4.21.92 | Clp protease | - |
Pseudomonas aeruginosa |
| 3.4.21.92 | Clp protease | - |
Rhodobacter capsulatus |
| 3.4.21.92 | Clp protease | - |
Enterococcus faecalis |
| 3.4.21.92 | Clp protease | - |
Streptococcus pyogenes |
| 3.4.21.92 | Clp protease | - |
Myxococcus xanthus |
| 3.4.21.92 | Clp protease | - |
Streptomyces coelicolor |
| 3.4.21.92 | Clp protease | - |
Helicobacter pylori |
| 3.4.21.92 | Clp protease | - |
Clostridium acetobutylicum |
| 3.4.21.92 | Clp protease | - |
Porphyromonas gingivalis |
| 3.4.21.92 | Clp protease | - |
Populus tremula |
| 3.4.21.92 | Clp protease | - |
Bordetella pertussis |
| 3.4.21.92 | Clp protease | - |
Deinococcus radiodurans |
| 3.4.21.92 | Clp protease | - |
Listeria monocytogenes |
| 3.4.21.92 | Clp protease | - |
Chlorobaculum tepidum |
| 3.4.21.92 | Clp protease | - |
Shewanella putrefaciens |
| 3.4.21.92 | Clp protease | - |
Chlamydomonas reinhardtii |
| 3.4.21.92 | Clp protease | - |
Chlorella vulgaris |
| 3.4.21.92 | Clp protease | - |
Cyanophora paradoxa |
| 3.4.21.92 | Clp protease | - |
Epifagus virginiana |
| 3.4.21.92 | Clp protease | - |
Fritillaria agrestis |
| 3.4.21.92 | Clp protease | - |
Haemophilus influenzae |
| 3.4.21.92 | Clp protease | - |
Homo sapiens |
| 3.4.21.92 | Clp protease | - |
Lactococcus lactis |
| 3.4.21.92 | Clp protease | - |
Solanum lycopersicum |
| 3.4.21.92 | Clp protease | - |
Marchantia polymorpha |
| 3.4.21.92 | Clp protease | - |
Mus musculus |
| 3.4.21.92 | Clp protease | - |
Bacillus subtilis |
| 3.4.21.92 | Clp protease | - |
Nicotiana tabacum |
| 3.4.21.92 | Clp protease | - |
Oryza sativa |
| 3.4.21.92 | Clp protease | - |
Paracoccus denitrificans |
| 3.4.21.92 | Clp protease | - |
Pinus contorta |
| 3.4.21.92 | Clp protease | - |
Pinus thunbergii |
| 3.4.21.92 | Clp protease | - |
Streptococcus salivarius |
| 3.4.21.92 | Clp protease | - |
Synechococcus sp. |
| 3.4.21.92 | Clp protease | - |
Synechocystis sp. |
| 3.4.21.92 | Clp protease | - |
Borreliella burgdorferi |
| 3.4.21.92 | Clp protease | - |
Treponema pallidum |
| 3.4.21.92 | Clp protease | - |
Triticum aestivum |
| 3.4.21.92 | Clp protease | - |
Yersinia enterocolitica |
| 3.4.21.92 | Clp protease | - |
Zea mays |
| 3.4.21.92 | Clp protease | - |
Caenorhabditis elegans |
| 3.4.21.92 | Clp protease | - |
Caulobacter vibrioides |
| 3.4.21.92 | Clp protease | - |
Chlamydia trachomatis |
| 3.4.21.92 | Clp protease | - |
Chlamydomonas moewusii |
| 3.4.21.92 | Clp protease | - |
Arabidopsis thaliana |
| 3.4.21.92 | Clp protease | - |
Mycobacterium tuberculosis |
| 3.4.21.92 | Clp protease | - |
Aquifex aeolicus |
| 3.4.21.92 | ClpC | - |
Listeria monocytogenes |
| 3.4.21.92 | ClpQ | - |
Escherichia coli |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.92 | ATP | ATP dependent, for full proteolytic activity ClpP must associate with one of two related ATPase subunits, ClpA or ClpX, other nucleoside triphosphates cannot substitute for ATP | Escherichia coli | |
| 3.4.21.92 | ATP | ATP dependent, for full proteolytic activity ClpP must associate with one of two related ATPase subunits, ClpA or ClpX, other nucleoside triphosphates cannot substitute for ATP | Bacillus subtilis | |
| 3.4.21.92 | ATP | ATP dependent, for full proteolytic activity ClpP must associate with one of two related ATPase subunits, ClpA or ClpX, other nucleoside triphosphates cannot substitute for ATP | Yersinia enterocolitica | |
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