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Literature summary extracted from

  • Won, J.S.; Im, Y.B.; Khan, M.; Singh, A.K.; Singh, I.
    The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase (2004), J. Neurochem., 88, 583-593.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 3-O-methylsphingomyelin
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 sphingomyelin + H2O Rattus norvegicus ceramide production by neutral sphingomyelinase is a key mediator in the induction of inducible nitric oxide synthase N-acylsphingosine + choline phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 glioma cell C6-glioma cells Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 sphingomyelin + H2O
-
 Rattus norvegicus N-acylsphingosine + choline phosphate
-
 ?
3.1.4.12 sphingomyelin + H2O ceramide production by neutral sphingomyelinase is a key mediator in the induction of inducible nitric oxide synthase Rattus norvegicus N-acylsphingosine + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 neutral sphingomyelinase
-
 Rattus norvegicus
3.1.4.12 nSMase
-
 Rattus norvegicus