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Literature summary extracted from

  • Fauroux, C.M.J.; Lee, M.; Cullis, P.M.; Douglas, K.T.; Gore, M.G.; Freeman, S.
    Stereochemistry at phosphorus of the reaction catalyzed by myo-inositol monophosphatase (2002), J. Med. Chem., 45, 1363-1373.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.25 phosphate product inhibition, competitive Bos taurus
3.1.3.25 phosphosulfate
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.25 0.11
-
 inositol 3-phosphate pH 9.0, 25°C Bos taurus
3.1.3.25 0.21
-
 inositol 1,3-thiophosphate pH 9.0, 25°C Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.25 Mg2+ two molecules bound per subunit Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.25 29920
-
 ESI-MS Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.25 myo-inositol 1-phosphate + H2O Bos taurus
-
 myo-inositol + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.25 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.25 brain
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.25 inositol 1,3-thiophosphate + H2O
-
 Bos taurus ?
-
 ?
3.1.3.25 myo-inositol 1,3-thiophosphate + H2O reaction 3times slower than reaction with inositol 1-phosphate Bos taurus ?
-
 ?
3.1.3.25 myo-inositol 1-phosphate + H2O
-
 Bos taurus myo-inositol + phosphate
-
 ?
3.1.3.25 myo-inositol 1-phosphate + H2O
-
 Bos taurus myo-inositol + phosphate inversion of phosphate configuration ?
3.1.3.25 myo-inositol 3-phosphate + H2O
-
 Bos taurus myo-inositol + phosphate inversion of phosphate configuration ?

Subunits

EC Number Subunits Comment Organism
3.1.3.25 dimer homodimer Bos taurus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.3.25 0.19
-
 inositol 1,3-thiophosphate pH 9.0, 25°C Bos taurus
3.1.3.25 0.48
-
 inositol 3-phosphate pH 9.0, 25°C Bos taurus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.3.25 7 9 no significant changes in activity Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.3.25 0.5
-
 phosphosulfate pH 6.5 and pH 9.0 Bos taurus