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Literature summary extracted from

  • Marchesini, N.; Osta, W.; Bielawski, J.; Luberto, C.; Obeid, L.M.; Hannun, Y.A.
    Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells (2004), J. Biol. Chem., 279, 25101-25111.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.12 expression in MCF7 breast cancer cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 additional information nSMase2 is distributed thoughout the cells in subconfluent, proliferating cultures Homo sapiens
-
-
3.1.4.12 plasma membrane nSMase2 is nearly exclusively located at the plasma membrane in confluent, contact-inhibited cells Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 additional information Homo sapiens nSMase2 functions as a growth suppressor in MCF-7 cells, linking confluence to the G0/G1 cell cycle check point ?
-
 ?
3.1.4.12 sphingomyelin + H2O Homo sapiens
-
 N-acylsphingosine + choline phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
-
-
3.1.4.12 Homo sapiens
-
 nSMase2 expression is up-regulated during cell growth
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 MCF-7 cell endogenous nSMase2 mRNA is upregulated 5fold when MCF-7 cells become growth-arrested at confluence, and total neutral SMase is increased 119% with respect to subconfluent cells Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 additional information nSMase2 functions as a growth suppressor in MCF-7 cells, linking confluence to the G0/G1 cell cycle check point Homo sapiens ?
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Homo sapiens N-acylsphingosine + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 neutral sphingomyelinase 2
-
 Homo sapiens
3.1.4.12 nSMase2
-
 Homo sapiens