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Literature summary extracted from
- Bicarbonate as a proton donor in catalysis by Zn(II)- and Co(II)-containing carbonic anhydrases (2001), J. Am. Chem. Soc., 123, 5861-5866.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.2.1.1 | expressed in Escherichia coli | Homo sapiens |
| 4.2.1.1 | expressed in Escherichia coli | Methanosarcina thermophila |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 4.2.1.1 | - |
Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 4.2.1.1 | H64A | site-specific mutant | Homo sapiens |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.1 | Co2+ | Co2+ containing | Homo sapiens |  |
| 4.2.1.1 | Zn2+ | Zn2+ containing | Homo sapiens | |
| 4.2.1.1 | Zn2+ | Zn2+ containing | Methanosarcina thermophila | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.1 | H2CO3 | Homo sapiens | - |
CO2 + H2O | - |
r | |
| 4.2.1.1 | H2CO3 | Methanosarcina thermophila | - |
CO2 + H2O | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.1 | Homo sapiens | - |
- |
- |
| 4.2.1.1 | Methanosarcina thermophila | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.2.1.1 | recombinant enzyme | Homo sapiens |
| 4.2.1.1 | recombinant enzyme | Methanosarcina thermophila |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.1 | H2CO3 | - |
Homo sapiens | CO2 + H2O | - |
r | |
| 4.2.1.1 | H2CO3 | - |
Methanosarcina thermophila | CO2 + H2O | - |
r | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.1.1 | Cam | - |
Methanosarcina thermophila |
| 4.2.1.1 | carbonic anhydrase | - |
Methanosarcina thermophila |
| 4.2.1.1 | human carbonic anhydrase II | - |
Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.1 | 7.8 | - |
- |
Methanosarcina thermophila |
| 4.2.1.1 | 7.8 | 8.5 | mutant H64A | Homo sapiens |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.1 | 7.2 | 9 | - |
Methanosarcina thermophila |
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Release 2023.1 (January 2023)
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