Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Liu, W.; Rogers, C.J.; Fisher, A.J.; Toney, M.D.
    Aminophosphonate inhibitors of dialkylglycine decarboxylase: structural basis for slow binding inhibition (2002), Biochemistry, 41, 12320-12328.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.1.1.64 in complex with different aminophosphonate inhibitors Burkholderia cepacia

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.64 (R)-1-amino-1-methylpropanephosphonate
-
 Burkholderia cepacia
4.1.1.64 (R)-1-amino-1-phenylethanephosphonate
-
 Burkholderia cepacia
4.1.1.64 (R)-1-aminoethanephosphonate
-
 Burkholderia cepacia
4.1.1.64 (S)-1-aminoethanephosphonate
-
 Burkholderia cepacia
4.1.1.64 1-aminocyclopentanephosphonate
-
 Burkholderia cepacia

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.64 Burkholderia cepacia P16932
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.1.1.64 2,2-dialkylglycine + pyruvate = dialkyl ketone + CO2 + L-alanine kinetics of inhibition Burkholderia cepacia
a

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.1.64 1.1
-
 (S)-1-aminoethanephosphonate pH 7.8, homologous to D-alanine Burkholderia cepacia
4.1.1.64 4.9
-
 (R)-1-amino-1-methylpropanephosphonate pH 7.8, homologous to L-isovaline Burkholderia cepacia
4.1.1.64 6
-
 1-aminocyclopentanephosphonate pH 7.8, homologous to aminocyclopropane carboxylate Burkholderia cepacia
4.1.1.64 13
-
 (R)-1-amino-1-phenylethanephosphonate pH 7.8, homologous to L-phenylglycine Burkholderia cepacia
4.1.1.64 19
-
 (R)-1-aminoethanephosphonate pH 7.8, homologous to L-alanine Burkholderia cepacia