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Literature summary extracted from
- Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites (1999), Biochemistry, 38, 2738-2744.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.22 | CO | reversible competitive with respect to homocysteine, complete loss of activity at 0.06 mM | Homo sapiens |  |
| 4.2.1.22 | cyanide | - |
Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.22 | Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.22 | L-Serine + homocysteine | - |
Homo sapiens | Cystathionine + H2O | - |
? | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.22 | heme | - |
Homo sapiens | |
| 4.2.1.22 | pyridoxal 5'-phosphate | 4 pyridoxal phosphate molecules per tetramer | Homo sapiens | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.1.22 | 2.3 | - |
cyanide | 37°C | Homo sapiens | |
| 4.2.1.22 | 5.6 | - |
CO | 37°C under anaerobic conditions | Homo sapiens | |
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Release 2023.1 (January 2023)
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