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Literature summary extracted from

  • Craxton, A.; Ali, N.; Shears, S.B.
    Comparison of the activities of a multiple inositol polyphosphate phosphatase obtained from several sources: a search for heterogeneity in this enzyme (1995), Biochem. J., 305, 491-498.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.62 Inositol 1,3,4,5,6-pentakisphosphate
-
 Rattus norvegicus
3.1.3.62 Inositol hexakisphosphate
-
 Rattus norvegicus
3.1.3.62 additional information extracts of liver, heart, kidney, testis and brain contain different amounts of endogenous inhibitors of enzyme activity Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.62 endoplasmic reticulum liver enzyme, inside, approximately evenly distributed between the rough and smooth subfractions Rattus norvegicus 5783
-
3.1.3.62 particle-bound liver enzyme Rattus norvegicus
-
-
3.1.3.62 plasma membrane erythrocytes Meleagris gallopavo 5886
-
3.1.3.62 plasma membrane erythrocytes Rattus norvegicus 5886
-
3.1.3.62 soluble liver enzyme Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.62 36000
-
 gel filtration Rattus norvegicus
3.1.3.62 36000
-
 liver enzyme Rattus norvegicus
3.1.3.62 47000
-
 1 * 47000, liver enzyme, doublet, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.62 additional information Rattus norvegicus function is unrelated to the metabolism of Ca2+-mobilizing cellular signals ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.62 Meleagris gallopavo
-
-
-
3.1.3.62 Rattus norvegicus
-
 male sprague-dawley rats
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.62 22400fold from liver Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.62 brain lowest specific activity Rattus norvegicus
-
3.1.3.62 erythrocyte plasma membrane Meleagris gallopavo
-
3.1.3.62 erythrocyte plasma membrane Rattus norvegicus
-
3.1.3.62 heart
-
 Rattus norvegicus
-
3.1.3.62 kidney highest specific activity Rattus norvegicus
-
3.1.3.62 liver
-
 Rattus norvegicus
-
3.1.3.62 testis
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.62 additional information
-
-
 Rattus norvegicus
3.1.3.62 4.29
-
 pH 7.4, liver enzyme Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
3.1.3.62 -20°C, 20% v/v glycerol, 1 mg/ml bovine serum albumin, up to 12 months, stable Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.62 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Rattus norvegicus D-myo-inositol 1,4,5-trisphosphate + phosphate
-
 ?
3.1.3.62 additional information function is unrelated to the metabolism of Ca2+-mobilizing cellular signals Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.62 monomer 1 * 47000, liver enzyme, doublet, SDS-PAGE Rattus norvegicus