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Literature summary extracted from

  • Hopkins, T.A.; Dyck, J.R.B.; Lopaschuk, G.D.
    AMP-activated protein kinase regulation of fatty acid oxidation in the ischaemic heart (2003), Biochem. Soc. Trans., 31, 207-212.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.31 5'-AMP
-
 Homo sapiens

Application

EC Number Application Comment Organism
2.7.11.31 medicine decreasing the ischaemic-induced activation of AMPK may be a therapeutic approach to treating ischaemic heart disease, AMPK may be an important pharmacological target for improving cardiac efficiency following ischaemia Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.27 ATP + [acetyl-CoA carboxylase] Homo sapiens AMPK causes phosphorylation and inhibition of acetyl-CoA carboxylase, which reduces the production of malonyl-CoA ADP + [acetyl-CoA carboxylase] phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.27 Homo sapiens
-
-
-
2.7.11.31 Homo sapiens
-
 human
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.27 heart
-
 Homo sapiens
-
2.7.11.31 heart
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.27 ATP + [acetyl-CoA carboxylase]
-
 Homo sapiens ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
2.7.11.27 ATP + [acetyl-CoA carboxylase] AMPK causes phosphorylation and inhibition of acetyl-CoA carboxylase, which reduces the production of malonyl-CoA Homo sapiens ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
2.7.11.31 ATP + acetyl-CoA carboxylase AMPK plays an important role in regulating malonyl-CoA levels through the phosphorylation of acetyl-CoA carboxylase Homo sapiens ADP + [acetyl-CoA carboxylase] phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.27 AMPK
-
 Homo sapiens