Literature summary extracted from

Darras, V.M.; Berghman, L.R.; Vanderpooten, A.; Kuhn, E.R.
Growth hormone acutely decreases type III iodothyronine deiodinase in chicken liver (1992), FEBS Lett., 310, 5-8.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.21.99.3	additional information	growth hormone increases plasma T3 and decreases plasma T4 levels in 8-day old chicken embryos, in newly hatched chicks and in adult chickens within 2 h after injection. Growth hormone has no effect at all on the amount of hepatic type I enzyme catalyzing T4 deiodination to T3 but acutely decreases the amount of type III enzyme catalyzing T3 deiodination	Gallus gallus
1.21.99.4	additional information	growth hormone increases plasma T3 and decreases plasma T4 levels in 8-day old chicken embryos, in newly hatched chicks and in adult chickens within 2 h after injection. Growth hormone has no effect at all on the amount of hepatic type I enzyme catalyzing T4 deiodination to T3 but acutely decreases the amount of type III enzyme catalyzing T3 deiodination	Gallus gallus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.21.99.3	Gallus gallus	-	type III enzyme	-
1.21.99.4	Gallus gallus	-	type I enzyme	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.21.99.3	liver	-	Gallus gallus	-
1.21.99.4	liver	-	Gallus gallus	-

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Release 2023.1 (January 2023)