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Literature summary extracted from

  • Bray, R.C.
    Xanthine oxidase (1963), The Enzymes, 2nd Ed. (Boyer, P. D. , Lardy, H. , Myrbäck, K. , eds. ), 7, 533-556.
No PubMed abstract available

General Stability

EC Number General Stability Organism
1.17.3.2 phosphate stabilizes Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 1,2-Dihydroxybenzene 3,5-disulfonic acid inhibits reaction with cytochrome c Bos taurus
1.17.3.2 3,3',4,4'-Tetrahydroxychalcone
-
 Bos taurus
1.17.3.2 4-iminocyclohexa-2,5-dien-1-one
-
 Bos taurus
1.17.3.2 copper
-
 Bos taurus
1.17.3.2 hydroxylamine
-
 Bos taurus
1.17.3.2 myoglobin inhibits reaction with cytochrome c as acceptor Bos taurus
1.17.3.2 phenylhydrazine
-
 Bos taurus
1.17.3.2 Pterines or other heterocyclic compounds, which are either not oxidized or oxidized rather slowly Bos taurus
1.17.3.2 Purines
-
 Bos taurus
1.17.3.2 salicylate
-
 Bos taurus
1.17.3.2 Semicarbazide
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.17.3.2 additional information
-
 additional information
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.3.2 microsome enzyme from milk and mammary gland Bos taurus
-
-
1.17.3.2 additional information liver enzyme: in supernatant fraction Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.17.3.2 Iron iron-molybdenum protein Bos taurus
1.17.3.2 Iron contains FAD, iron and molybdenum in the ratio 1/4/4 Bos taurus
1.17.3.2 Molybdenum contains FAD, molybdenum and iron in the ratio 1/4/4 Bos taurus
1.17.3.2 Molybdenum an iron-molybdenum protein Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Bos taurus
-
-
-

Oxidation Stability

EC Number Oxidation Stability Organism
1.17.3.2 photooxidation, protection by competitive inhibitors Bos taurus

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.17.3.2 additional information
-
 Bos taurus
1.17.3.2 proteolytic modification
-
 Bos taurus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.17.3.2 xanthine + H2O + O2 = urate + H2O2 mechanism Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.3.2 liver
-
 Bos taurus
-
1.17.3.2 milk
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 hypoxanthine + 2 H2O + 2 O2
-
 Bos taurus urate + 2 H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 electron acceptor methylene blue Bos taurus uric acid + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 electron acceptor NAD+ Bos taurus uric acid + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 electron acceptor O2 Bos taurus uric acid + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 specificity for electron acceptor is low Bos taurus uric acid + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 electron acceptor triphenyltetrazolium chloride, phenazine methosulfate, nitrate, cytochrome c, ferritin Bos taurus uric acid + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 low specificity to substrate Bos taurus uric acid + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 electron acceptor ferricyanide Bos taurus uric acid + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 electron acceptor 2,6-dichlorophenolindophenol Bos taurus uric acid + H2O2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.3.2 FAD flavoprotein Bos taurus
1.17.3.2 FAD contains FAD, molybdenum and iron in the ratio 1 : 4 : 4 Bos taurus