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Literature summary extracted from

  • Lam, B.K.; Frank Austen, K.
    Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes (2002), Prostaglandins Other Lipid Mediat., 68-69, 511-520.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
4.4.1.20 A52S mutation increases the Km-value for the recombinant enzyme for glutathione Homo sapiens
4.4.1.20 C56S mutant enzyme without altered function Homo sapiens
4.4.1.20 C56S/C82 mutant enzyme without altered function Homo sapiens
4.4.1.20 C82V mutant enzyme without altered function Homo sapiens
4.4.1.20 N55A mutation increases the Km-value for the recombinant enzyme for glutathione Homo sapiens
4.4.1.20 R51H fully active mutant enzyme Homo sapiens
4.4.1.20 R51I mutant enzyme without activity Homo sapiens
4.4.1.20 R51K fully active mutant enzyme Homo sapiens
4.4.1.20 R51T mutant enzyme without activity Homo sapiens
4.4.1.20 V49F mutation increases the Km-value for the recombinant enzyme for glutathione Homo sapiens
4.4.1.20 Y59F mutation increases the Km-value for the recombinant enzyme for glutathione Homo sapiens
4.4.1.20 Y93F activity of the mutant enzyme is less than 1% of the wild-type enzyme, shift in pH optimum of the residual activity to that of spontaneous conjugation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.20 NEM
-
 Cavia porcellus
4.4.1.20 NEM
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.4.1.20 Mg2+
-
 Homo sapiens
4.4.1.20 Mg2+ enhances activity Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.20 Cavia porcellus
-
-
-
4.4.1.20 Homo sapiens
-
-
-
4.4.1.20 Mus musculus
-
-
-
4.4.1.20 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.20 leukotriene A4 + glutathione
-
 Cavia porcellus leukotriene C4 + H2O
-
 ?
4.4.1.20 leukotriene A4 + glutathione
-
 Mus musculus leukotriene C4 + H2O
-
 ?
4.4.1.20 leukotriene A4 + glutathione
-
 Homo sapiens leukotriene C4 + H2O
-
 ?
4.4.1.20 leukotriene A4 + glutathione
-
 Rattus norvegicus leukotriene C4 + H2O
-
 ?