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Literature summary extracted from

  • Thompson, T.B.; Thomas, M.G.; Escalante-Semerena, J.C.; Rayment, I.
    Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase from Salmonella typhimurium determined to 2.3 Å resolution (1998), Biochemistry, 37, 7686-7695.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.1.156 X-ray structure determined to 2.3 A resolution, crystals grown by microbatch, enzyme is crystallized in space group C222(1) with unit cell dimensions of a : 96.4 A, b : 114.4 A, and c : 106.7 A Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.62 X-ray structure determined to 2.3 A resolution, crystals grown by microbatch, enzyme is crystallized in space group C222(1) with unit cell dimensions of a : 96.4 A, b : 114.4 A, and c : 106.7 A Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.156 19770
-
 3 * 19770 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.62 19770
-
 3 * 19770 Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.156 ATP + adenosylcobinamide Salmonella enterica subsp. enterica serovar Typhimurium
-
 adenosylcobinamide phosphate + ADP
-
 ?
2.7.1.156 ATP + adenosylcobinamide Salmonella enterica subsp. enterica serovar Typhimurium cobalamin biosynthesis, involved in de novo synthesis of vitamin B12 adenosylcobinamide phosphate + ADP
-
 ?
2.7.1.156 GTP + adenosylcobinamide Salmonella enterica subsp. enterica serovar Typhimurium
-
 adenosylcobinamide phosphate + GDP
-
 ?
2.7.7.62 GTP + adenosylcobinamide phosphate Salmonella enterica subsp. enterica serovar Typhimurium
-
 diphosphate + adenosylcobinamide-GDP
-
 ?
2.7.7.62 GTP + adenosylcobinamide phosphate Salmonella enterica subsp. enterica serovar Typhimurium cobalamin biosynthesis, involved in de novo synthesis of vitamin B12 diphosphate + adenosylcobinamide-GDP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.156 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
2.7.7.62 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.156
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.62
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.156 ATP + adenosylcobinamide
-
 Salmonella enterica subsp. enterica serovar Typhimurium adenosylcobinamide phosphate + ADP
-
 ?
2.7.1.156 ATP + adenosylcobinamide cobalamin biosynthesis, involved in de novo synthesis of vitamin B12 Salmonella enterica subsp. enterica serovar Typhimurium adenosylcobinamide phosphate + ADP
-
 ?
2.7.1.156 GTP + adenosylcobinamide
-
 Salmonella enterica subsp. enterica serovar Typhimurium adenosylcobinamide phosphate + GDP
-
 ?
2.7.7.62 GTP + adenosylcobinamide phosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium diphosphate + adenosylcobinamide-GDP
-
 ?
2.7.7.62 GTP + adenosylcobinamide phosphate cobalamin biosynthesis, involved in de novo synthesis of vitamin B12 Salmonella enterica subsp. enterica serovar Typhimurium diphosphate + adenosylcobinamide-GDP
-
 ?
2.7.7.62 additional information CobU is a bifunctional enzyme that has both kinase EC 2.7.1.156 and guanyltransferase EC 2.7.7.62 activities Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.156 trimer 3 * 19770 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.62 trimer 3 * 19770 Salmonella enterica subsp. enterica serovar Typhimurium

Synonyms

EC Number Synonyms Comment Organism
2.7.1.156 adenosylcobinamide kinase
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.156 CobU
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.62 adenosylcobinamide phosphate guanylyltransferase
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.7.62 CobU
-
 Salmonella enterica subsp. enterica serovar Typhimurium