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Literature summary extracted from

  • Ono, K.; Ogasawara, M.; Iwata, Y.; Nakane, H.; Fujii, T.; Sawai, K.; Saneyoshi, M.
    Inhibition of reverse transcriptase activity by 2,3-dideoxythymidine 5-triphosphate and its derivatives modified on the 3 position (1986), Biochem. Biophys. Res. Commun., 140, 498-507.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.49 2',3'-dideoxythymidine 5'-triphosphate Mn2+ is requisite for the compound to exhibit inhibition, competitive with dTTP Rauscher murine leukemia virus
2.7.7.49 2'-deoxyxylofuranosylthymidine 5'-triphosphate Mn2+ is requisite for the compound to exhibit inhibition, competitive with dTTP Rauscher murine leukemia virus
2.7.7.49 3'-Azido-2',3'-dideoxythymidine 5'-triphosphate Mn2+ is requisite for the compound to exhibit inhibition, competitive with dTTP Rauscher murine leukemia virus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.49 0.03
-
 dTTP pH 8.5, 37°C Rauscher murine leukemia virus

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.49 Rauscher murine leukemia virus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.49 deoxynucleoside triphosphate + DNAn
-
 Rauscher murine leukemia virus diphosphate + DNAn+1
-
 ?
2.7.7.49 dTTP + poly(rA)/(dT)18
-
 Rauscher murine leukemia virus ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.7.49 0.0018
-
 3'-Azido-2',3'-dideoxythymidine 5'-triphosphate pH 8.5, 37°C Rauscher murine leukemia virus
2.7.7.49 0.0093
-
 2',3'-dideoxythymidine 5'-triphosphate pH 8.5, 37°C Rauscher murine leukemia virus
2.7.7.49 0.0163
-
 2'-deoxyxylofuranosylthymidine 5'-triphosphate pH 8.5, 37°C Rauscher murine leukemia virus