EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.6.1 | 2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate | - |
Escherichia coli | |
2.7.6.1 | 2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate | - |
Homo sapiens | |
2.7.6.1 | 9-(2-phosphonylmethoxyethoxy)adenine | IC50 of 0.86 mM | Escherichia coli | |
2.7.6.1 | 9-(2-phosphonylmethoxyethoxy)adenine | IC50 of more than 2.5 mM | Homo sapiens | |
2.7.6.1 | 9-(2-phosphonylmethoxyethyl)adenine | IC50 of 1.9 mM | Escherichia coli | |
2.7.6.1 | 9-(2-phosphonylmethoxyethyl)adenine | IC50 of 2.1 mM | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.6.1 | 0.007 | - |
ATP | pH 8.0, 37ÂșC | Homo sapiens | |
2.7.6.1 | 0.008 | - |
ATP | pH 8.0, 37ÂșC, isoenzyme I | Rattus norvegicus | |
2.7.6.1 | 0.023 | - |
ATP | pH 8.0, 37ÂșC | Escherichia coli | |
2.7.6.1 | 0.051 | - |
ATP | pH 8.0, 37ÂșC, isoenzyme II | Rattus norvegicus | |
2.7.6.1 | 0.122 | - |
AMP | pH 8.0, 37ÂșC | Homo sapiens | |
2.7.6.1 | 0.132 | - |
AMP | pH 8.0, 37ÂșC | Escherichia coli | |
2.7.6.1 | 0.167 | - |
AMP | pH 8.0, 37ÂșC, isoenzyme II | Rattus norvegicus | |
2.7.6.1 | 0.263 | - |
AMP | pH 8.0, 37ÂșC, isoenzyme I | Rattus norvegicus | |
2.7.6.1 | 0.308 | - |
9-(2-phosphonylmethoxyethoxy)adenine | pH 8.0, 37ÂșC, isoenzyme I | Rattus norvegicus | |
2.7.6.1 | 0.317 | - |
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate | pH 8.0, 37ÂșC, isoenzyme II | Rattus norvegicus | |
2.7.6.1 | 0.323 | - |
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate | pH 8.0, 37ÂșC, isoenzyme I | Rattus norvegicus | |
2.7.6.1 | 0.377 | - |
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate | pH 8.0, 37ÂșC | Escherichia coli | |
2.7.6.1 | 0.422 | - |
9-(2-phosphonylmethoxyethoxy)adenine | pH 8.0, 37ÂșC | Homo sapiens | |
2.7.6.1 | 0.575 | - |
(S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine | pH 8.0, 37ÂșC | Escherichia coli | |
2.7.6.1 | 0.588 | - |
9-(2-phosphonylmethoxyethoxy)adenine | pH 8.0, 37ÂșC | Escherichia coli | |
2.7.6.1 | 0.656 | - |
9-(2-phosphonylmethoxyethyl)adenine | pH 8.0, 37ÂșC, isoenzyme I | Rattus norvegicus | |
2.7.6.1 | 0.661 | - |
9-(2-phosphonylmethoxyethyl)adenine | pH 8.0, 37ÂșC | Homo sapiens | |
2.7.6.1 | 0.789 | - |
9-(2-phosphonylmethoxyethoxy)adenine | pH 8.0, 37ÂșC, isoenzyme II | Rattus norvegicus | |
2.7.6.1 | 1.013 | - |
9-(2-phosphonylmethoxyethyl)adenine | pH 8.0, 37ÂșC, isoenzyme II | Rattus norvegicus | |
2.7.6.1 | 1.14 | - |
(R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine | pH 8.0, 37ÂșC | Escherichia coli | |
2.7.6.1 | 1.29 | - |
(R)9-(2-phosphonylmethoxypropyl)adenine | pH 8.0, 37ÂșC | Escherichia coli | |
2.7.6.1 | 1.47 | - |
9-(2-phosphonylmethoxyethyl)adenine | pH 8.0, 37ÂșC | Escherichia coli | |
2.7.6.1 | 1.54 | - |
(S)9-(2-phosphonylmethoxypropyl)adenine | pH 8.0, 37ÂșC | Escherichia coli | |
2.7.6.1 | 1.923 | - |
(R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine | pH 8.0, 37ÂșC, isoenzyme I | Rattus norvegicus | |
2.7.6.1 | 2.174 | - |
(S)9-(2-phosphonylmethoxypropyl)adenine | pH 8.0, 37ÂșC | Homo sapiens | |
2.7.6.1 | 3.571 | - |
(R)9-(2-phosphonylmethoxypropyl)adenine | pH 8.0, 37ÂșC | Homo sapiens | |
2.7.6.1 | 3.636 | - |
(S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine | pH 8.0, 37ÂșC, isoenzyme I | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.6.1 | ATP + D-ribose 5-phosphate | Escherichia coli | - |
AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
2.7.6.1 | ATP + D-ribose 5-phosphate | Homo sapiens | the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
2.7.6.1 | ATP + D-ribose 5-phosphate | Rattus norvegicus | the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.6.1 | Escherichia coli | - |
- |
- |
2.7.6.1 | Homo sapiens | - |
- |
- |
2.7.6.1 | Rattus norvegicus | - |
rat | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.6.1 | erythrocyte | - |
Homo sapiens | - |
2.7.6.1 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.6.1 | (R)9-(2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Escherichia coli | (R)9-(2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | (R)9-(2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | (R)9-(2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | (R)9-(2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Rattus norvegicus | (R)9-(2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | (R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Escherichia coli | (R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | (R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | (R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | (R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Rattus norvegicus | (R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | (S)9-(2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Escherichia coli | (S)9-(2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | (S)9-(2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | (S)9-(2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | (S)9-(2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Rattus norvegicus | (S)9-(2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | (S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Escherichia coli | (S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | (S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | (S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | (S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Rattus norvegicus | (S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | 2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Escherichia coli | 2',3'-dideoxy-2',3'-didehydro-adenosine-5'-triphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | 2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | 2',3'-dideoxy-2',3'-didehydro-adenosine-5'-triphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | 2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Rattus norvegicus | 2',3'-dideoxy-2',3'-didehydro-adenosine-5'-triphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | 9-(2-phosphonylmethoxyethoxy)adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Escherichia coli | 9-(2-phosphonylmethoxyethoxy)adenine-diphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | 9-(2-phosphonylmethoxyethoxy)adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | 9-(2-phosphonylmethoxyethoxy)adenine-diphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | 9-(2-phosphonylmethoxyethoxy)adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Rattus norvegicus | 9-(2-phosphonylmethoxyethoxy)adenine-diphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | 9-(2-phosphonylmethoxyethyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Escherichia coli | 9-(2-phosphonylmethoxyethyl)adenine-diphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | 9-(2-phosphonylmethoxyethyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | 9-(2-phosphonylmethoxyethyl)adenine-diphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | 9-(2-phosphonylmethoxyethyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Rattus norvegicus | 9-(2-phosphonylmethoxyethyl)adenine-diphosphate + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Escherichia coli | ATP + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | ATP + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Rattus norvegicus | ATP + D-ribose 5-phosphate | - |
r | |
2.7.6.1 | ATP + D-ribose 5-phosphate | - |
Escherichia coli | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
2.7.6.1 | ATP + D-ribose 5-phosphate | - |
Homo sapiens | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
2.7.6.1 | ATP + D-ribose 5-phosphate | - |
Rattus norvegicus | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
2.7.6.1 | ATP + D-ribose 5-phosphate | the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan | Homo sapiens | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
2.7.6.1 | ATP + D-ribose 5-phosphate | the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan | Rattus norvegicus | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.6.1 | 37 | - |
assay at | Escherichia coli |
2.7.6.1 | 37 | - |
assay at | Homo sapiens |
2.7.6.1 | 37 | - |
assay at | Rattus norvegicus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.6.1 | 0.37 | - |
9-(2-phosphonylmethoxyethyl)adenine | pH 8.0,37ÂșC | Homo sapiens | |
2.7.6.1 | 0.41 | - |
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate | pH 8.0, 37ÂșC | Homo sapiens | |
2.7.6.1 | 0.55 | - |
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate | pH 8.0, 37ÂșC | Escherichia coli | |
2.7.6.1 | 1.4 | - |
9-(2-phosphonylmethoxyethoxy)adenine | pH 8.0, 37ÂșC | Escherichia coli | |
2.7.6.1 | 1.9 | - |
9-(2-phosphonylmethoxyethyl)adenine | pH 8.0, 37ÂșC | Escherichia coli |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.7.6.1 | 0.86 | - |
IC50 of 0.86 mM | Escherichia coli | 9-(2-phosphonylmethoxyethoxy)adenine | |
2.7.6.1 | 1.9 | - |
IC50 of 1.9 mM | Escherichia coli | 9-(2-phosphonylmethoxyethyl)adenine | |
2.7.6.1 | 2.1 | - |
IC50 of 2.1 mM | Homo sapiens | 9-(2-phosphonylmethoxyethyl)adenine | |
2.7.6.1 | 2.5 | - |
IC50 of more than 2.5 mM | Homo sapiens | 9-(2-phosphonylmethoxyethoxy)adenine |