EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.6.1 | phosphate | - |
Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.6.1 | 2,3-diphosphoglycerate | 30% inhibition at 1 mM; competitive to D-ribose 5-phosphate | Homo sapiens | |
2.7.6.1 | 2-deoxy-D-ribose 5-phosphate | 92% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | 5-phospho-alpha-D-ribose 1-diphosphate | competitive to ribose 5-phosphate | Homo sapiens | |
2.7.6.1 | adenosine | 27% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | ADP | 99% inhibition at 1 mM; competitive inhibition to ATP; end product inhibition; the most effective | Homo sapiens | |
2.7.6.1 | allopurinol ribonucleotides | 23% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | AMP | 69% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | CDP | 44% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | CTP | 40% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | D-fructose 1,6-diphosphate | 20% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | D-Fructose 1-phosphate | 19% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | D-ribose 1-phosphate | 13% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | FAD | 51% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | GDP | - |
Homo sapiens | |
2.7.6.1 | glyceraldehyde 3-phosphate | 14% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | GMP | 27% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | GTP | 51% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | guanosine | 20% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | IDP | 47% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | IMP | 21% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | ITP | 36% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | additional information | inhibition by pair of inhibitors tested is not greater than the sum of the inhibition produced by each alone | Homo sapiens | |
2.7.6.1 | NAD+ | 100% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | NADH | 72% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | NADPH | 100% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | TDP | 100% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | TTP | 47% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | UDP | 10%-16% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | UMP | 10%-18% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | XDP | 36% inhibition at 1 mM | Homo sapiens | |
2.7.6.1 | XTP | 22% inhibition at 1 mM | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.6.1 | 0.0002 | - |
Mg2+ | pH 7.4, 37ºC | Homo sapiens | |
2.7.6.1 | 0.014 | - |
ATP | pH 7.4, 37ºC | Homo sapiens | |
2.7.6.1 | 0.014 | - |
ATP | ATP in form of MgATP2- | Homo sapiens | |
2.7.6.1 | 0.033 | - |
ribose 5-phosphate | pH 7.4, 37ºC | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.6.1 | ATP + D-ribose 5-phosphate | Homo sapiens | the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.6.1 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.6.1 | partial, 400fold purification | Homo sapiens |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.7.6.1 | ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate | ordered bi-bi reaction with ribose-5-phosphate binding first and 5-phosphoribose diphosphate being released last | Homo sapiens | |
2.7.6.1 | ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate | ordered bi-bi reaction | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.6.1 | erythrocyte | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.6.1 | ATP + D-ribose 5-phosphate | - |
Homo sapiens | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
2.7.6.1 | ATP + D-ribose 5-phosphate | the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan | Homo sapiens | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.6.1 | 37 | - |
assay at | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.6.1 | 0.1 | - |
5-phospho-alpha-D-ribose 1-diphosphate | pH 7.4, 37ºC | Homo sapiens | |
2.7.6.1 | 0.3 | - |
AMP | pH 7.4, 37ºC, with D-ribose-5-phosphate | Homo sapiens | |
2.7.6.1 | 0.4 | - |
AMP | pH 7.4, 37ºC, with MgATP2- | Homo sapiens |