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Literature summary extracted from

  • Hinson, D.D.; Chambliss, K.L.; Toth, M.J.; Tanaka, R.D.; Gibson, K.M.
    Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways (1997), J. Lipid Res., 38, 2216-2223.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.36 expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.36 3,3-dimethylallyl diphosphate
-
 Homo sapiens
2.7.1.36 dolichol phosphate
-
 Homo sapiens
2.7.1.36 farnesol
-
 Homo sapiens
2.7.1.36 farnesyl diphosphate
-
 Homo sapiens
2.7.1.36 geranyl diphosphate
-
 Homo sapiens
2.7.1.36 geranylgeranyl diphosphate
-
 Homo sapiens
2.7.1.36 isopentenyl diphosphate
-
 Homo sapiens
2.7.1.36 additional information not inhibited by R-mevalonate 5-diphosphate, geraniol and dolichol up to 0.084, 0.226 and 0.68 mM, respectively Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.36 0.15
-
 (R,S)-mevalonate pH 7.0, 25°C, recombinant mevalonate kinase Homo sapiens
2.7.1.36 0.44
-
 ATP pH 7.0, 25°C, recombinant mevalonate kinase Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.36 42500
-
 x * 42500, recombinant mevalonate kinase, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.36 ATP + mevalonate Homo sapiens part of the cholesterol and nonsterol isoprene biosynthetic pathway ADP + phosphomevalonate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.36 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.36 recombinant mevalonat kinase-glutathione S-transferase fusion protein, glutathione Sepharose beads Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.36 ATP + mevalonate
-
 Homo sapiens ADP + phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate part of the cholesterol and nonsterol isoprene biosynthetic pathway Homo sapiens ADP + phosphomevalonate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.36 ? x * 42500, recombinant mevalonate kinase, SDS-PAGE Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.36 0.000104
-
 farnesyl diphosphate pH 7.0, 25°C, recombinant mevalonate kinase Homo sapiens
2.7.1.36 0.016
-
 isopentenyl diphosphate pH 7.0, 25°C, recombinant mevalonate kinase Homo sapiens
2.7.1.36 0.02
-
 3,3-dimethylallyl diphosphate pH 7.0, 25°C, recombinant mevalonate kinase Homo sapiens
2.7.1.36 0.059
-
 geranylgeranyl diphosphate pH 7.0, 25°C, recombinant mevalonate kinase Homo sapiens
2.7.1.36 0.072
-
 farnesol pH 7.0, 25°C, recombinant mevalonate kinase Homo sapiens
2.7.1.36 0.083
-
 dolichol phosphate pH 7.0, 25°C, recombinant mevalonate kinase Homo sapiens
2.7.1.36 0.116
-
 geranyl diphosphate pH 7.0, 25°C, recombinant mevalonate kinase Homo sapiens