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Literature summary extracted from

  • Linassier, C.; MacDougall, L.K.; Domin, J.; Waterfield, M.D.
    Molecular cloning and biochemical characterization of a Drosophila phosphatidylinositol-specific phosphoinositide 3-kinase (1997), Biochem. J., 321, 849-856.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.137 expression of the complete coding sequence as a glutathione S-transferase fusion protein in Sf9 cells Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.137 Nonidet P40
-
 Drosophila melanogaster
2.7.1.137 Wortmannin IC50 10 nM Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.137 Drosophila melanogaster P91635
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidylinositol
-
 Drosophila melanogaster ADP + phosphatidylinositol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.137 PI3K_59F
-
 Drosophila melanogaster

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.137 0.00001
-
 IC50 10 nM Drosophila melanogaster Wortmannin