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Literature summary extracted from

  • Fernandez, F.; Shridas, P.; Jiang, S.; Aebi, M.; Waechter, C.J.
    Expression and characterization of a human cDNA that complements the temperature-sensitive defect in dolichol kinase activity in the yeast sec59-1 mutant: the enzymatic phosphorylation of dolichol and diacylglycerol are catalyzed by separate CTP-mediated kinase activities in Saccharomyces cerevisiae (2002), Glycobiology, 12, 555-562.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.108
-
 Saccharomyces cerevisiae
2.7.1.108 human cDNA complements defect in dolichol kinase activity in Saccharomyces cerevisiae sec59-1 mutant, human SEC59 gene also expressed in Sf-9 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.108 membrane
-
 Homo sapiens 16020
-
2.7.1.108 membrane
-
 Saccharomyces cerevisiae 16020
-
2.7.1.108 microsome
-
 Homo sapiens
-
-
2.7.1.108 microsome
-
 Saccharomyces cerevisiae
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.108 59000 60000 SDS-PAGE Homo sapiens
2.7.1.108 59270
-
 predicted from cDNA open reading frame Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.108 CTP + dolichol Homo sapiens CTP mediated phosphorylation of dolichol, the terminal step in dolichyl monophospate biosynthesis de novo CDP + dolichyl phosphate
-
 ?
2.7.1.108 CTP + dolichol Saccharomyces cerevisiae CTP mediated phosphorylation of dolichol, the terminal step in dolichyl monophospate biosynthesis de novo CDP + dolichyl phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.108 Homo sapiens
-
 clone KIAA1094 from a human brain library
-
2.7.1.108 Saccharomyces cerevisiae P20048 yeast, SEC59 gene
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.108 brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.108 CTP + dolichol
-
 Homo sapiens CDP + dolichyl phosphate
-
 ?
2.7.1.108 CTP + dolichol
-
 Saccharomyces cerevisiae CDP + dolichyl phosphate
-
 ?
2.7.1.108 CTP + dolichol CTP mediated phosphorylation of dolichol, the terminal step in dolichyl monophospate biosynthesis de novo Homo sapiens CDP + dolichyl phosphate
-
 ?
2.7.1.108 CTP + dolichol CTP mediated phosphorylation of dolichol, the terminal step in dolichyl monophospate biosynthesis de novo Saccharomyces cerevisiae CDP + dolichyl phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.108 DK
-
 Homo sapiens
2.7.1.108 DK
-
 Saccharomyces cerevisiae