EC Number | General Stability | Organism |
---|---|---|
2.6.1.48 | 2-oxoglutarate and pyridoxal 5'-phosphate protects against thermal denaturation | Meyerozyma guilliermondii |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.48 | 2,3-Diaminopropionate | noncompetitive inhibition with respect to delta-aminovalerate, competitive inhibition to 2-oxoglutarate | Meyerozyma guilliermondii | |
2.6.1.48 | 2,4-diaminobutyrate | noncompetitive inhibition with respect to delta-aminovalerate, competitive inhibition to 2-oxoglutarate | Meyerozyma guilliermondii | |
2.6.1.48 | alanine | noncompetitive inhibition with respect to delta-aminovalerate, competitive inhibition to 2-oxoglutarate | Meyerozyma guilliermondii | |
2.6.1.48 | beta-Alanine | noncompetitive inhibition with respect to delta-aminovalerate, competitive inhibition to 2-oxoglutarate | Meyerozyma guilliermondii | |
2.6.1.48 | glycine | noncompetitive inhibition with respect to delta-aminovalerate, competitive inhibition to 2-oxoglutarate | Meyerozyma guilliermondii | |
2.6.1.48 | L-lysine | noncompetitive inhibition with respect to delta-aminovalerate, competitive inhibition to 2-oxoglutarate | Meyerozyma guilliermondii | |
2.6.1.48 | L-ornithine | mixed inhibition with respect to delta-aminovalerate, competitive inhibition to 2-oxoglutarate | Meyerozyma guilliermondii | |
2.6.1.48 | additional information | alpha-aminobutyrate, 4-aminobutyrate, alpha-aminovalerate and epsilon-aminocaproate does not cause any inhibition | Meyerozyma guilliermondii |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.6.1.48 | 3.6 | - |
2-oxoglutarate | pH 7.8, 35°C | Meyerozyma guilliermondii | |
2.6.1.48 | 4.9 | - |
delta-aminovaleric acid | pH 7.8, 35°C | Meyerozyma guilliermondii |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.6.1.48 | 60000 | - |
2 * 60000, SDS-PAGE | Meyerozyma guilliermondii |
2.6.1.48 | 118000 | - |
gel filtration | Meyerozyma guilliermondii |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.6.1.48 | 5-aminopentanoate + 2-oxoglutarate | Meyerozyma guilliermondii | enzyme is strongly induced in cells grown on delta-aminovalerate or on lysine as only nitrogen source | 5-oxovalerate + L-glutamate | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.6.1.48 | Meyerozyma guilliermondii | - |
var.membranaefaciens | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.6.1.48 | - |
Meyerozyma guilliermondii |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.6.1.48 | 20.8 | - |
- |
Meyerozyma guilliermondii |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.6.1.48 | 4-aminobutyrate + 2-oxoglutarate | relative activity 40% | Meyerozyma guilliermondii | succinic semialdehyde + L-glutamate | - |
r | |
2.6.1.48 | 5-aminopentanoate + 2-oxoglutarate | - |
Meyerozyma guilliermondii | 5-oxovalerate + L-glutamate | - |
r | |
2.6.1.48 | 5-aminopentanoate + 2-oxoglutarate | enzyme is strongly induced in cells grown on delta-aminovalerate or on lysine as only nitrogen source | Meyerozyma guilliermondii | 5-oxovalerate + L-glutamate | - |
r | |
2.6.1.48 | glycine + 2-oxoglutarate | relative activity 1% | Meyerozyma guilliermondii | glyoxalate + L-glutamate | - |
r | |
2.6.1.48 | L-leucine + 2-oxoglutarate | relative activity 10% | Meyerozyma guilliermondii | 4-methyl-2-oxopentanoate + L-glutamate | - |
r | |
2.6.1.48 | L-norleucine + 2-oxoglutarate | relative activity 4.8% | Meyerozyma guilliermondii | 2-oxohexanoate + L-glutamate | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.6.1.48 | dimer | 2 * 60000, SDS-PAGE | Meyerozyma guilliermondii |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.6.1.48 | 40 | - |
- |
Meyerozyma guilliermondii |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.6.1.48 | 50 | - |
preserves 50% of its activity after being heated for 7 min, in presence of 2-oxoglutarate | Meyerozyma guilliermondii |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.6.1.48 | 7.8 | 8.5 | - |
Meyerozyma guilliermondii |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.48 | pyridoxal 5'-phosphate | Km 0.0227 mM | Meyerozyma guilliermondii |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.6.1.48 | 5 | - |
beta-Alanine | pH 7.8, 35°C, competitive inhibition with respect to 2-oxoglutarate | Meyerozyma guilliermondii | |
2.6.1.48 | 5.6 | - |
L-ornithine | pH 7.8, 35°C, competitive inhibition with respect to 2-oxoglutarate | Meyerozyma guilliermondii | |
2.6.1.48 | 7 | - |
2,3-Diaminopropionate | pH 7.8, 35°C, competitive inhibition with respect to 2-oxoglutarate | Meyerozyma guilliermondii | |
2.6.1.48 | 9.5 | - |
ornithine | pH 7.8, 35°C, mixed inhibition | Meyerozyma guilliermondii | |
2.6.1.48 | 10 | - |
glycine | pH 7.8, 35°C, competitive inhibition with respect to 2-oxoglutarate | Meyerozyma guilliermondii | |
2.6.1.48 | 11.5 | - |
2,4-diaminobutyrate | pH 7.8, 35°C, competitive inhibition with respect to 2-oxoglutarate | Meyerozyma guilliermondii | |
2.6.1.48 | 12.5 | - |
L-lysine | pH 7.8, 35°C, competitive inhibition with respect to 2-oxoglutarate | Meyerozyma guilliermondii | |
2.6.1.48 | 15 | - |
alanine | pH 7.8, 35°C, competitive inhibition with respect to 2-oxoglutarate | Meyerozyma guilliermondii | |
2.6.1.48 | 16 | - |
beta-Alanine | pH 7.8, 35°C, noncompetitive inhibition with respect to delta-aminovalerate | Meyerozyma guilliermondii | |
2.6.1.48 | 50 | - |
2,3-Diaminopropionate | pH 7.8, 35°C, noncompetitive inhibition with respect to delta-aminovalerate | Meyerozyma guilliermondii | |
2.6.1.48 | 90 | - |
glycine | pH 7.8, 35°C, noncompetitive inhibition with respect to delta-aminovalerate | Meyerozyma guilliermondii | |
2.6.1.48 | 120 | - |
alanine | pH 7.8, 35°C, noncompetitive inhibition with respect to delta-aminovalerate | Meyerozyma guilliermondii | |
2.6.1.48 | 120 | - |
lysine | pH 7.8, 35°C, noncompetitive inhibition with respect to delta-aminovalerate | Meyerozyma guilliermondii | |
2.6.1.48 | 190 | - |
2,4-diaminobutyrate | pH 7.8, 35°C, noncompetitive inhibition with respect to delta-aminovalerate | Meyerozyma guilliermondii |