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Literature summary extracted from

  • Yu, J.; Koenig, R.J.
    Regulation of hepatocyte thyroxine 5'-deiodinase by T3 and nuclear receptor coactivators as a model of the sick euthyroid syndrome (2000), J. Biol. Chem., 275, 38296-38301.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.4 interleukin 1 and interleukin 6 interleukins are competing for transcriptional coactivators and inhibit thyronine 5'-deiodinase induction by 3,3',5-triiodothyronine Rattus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.99.4 3,3',5'-triiodothyronine + AH2 Mus musculus
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2 Homo sapiens
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2 Rattus sp. isoenzyme type I 3,3'-diiodothyronine + iodide + A + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.4 Homo sapiens
-
-
-
1.21.99.4 Mus musculus
-
-
-
1.21.99.4 Rattus sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.4 liver
-
 Mus musculus
-
1.21.99.4 liver
-
 Homo sapiens
-
1.21.99.4 liver
-
 Rattus sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.4 3,3',5'-triiodothyronine + AH2
-
 Mus musculus 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2
-
 Homo sapiens 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2 isoenzyme type I Rattus sp. 3,3'-diiodothyronine + iodide + A + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.99.4 iodothyronine 5'-deiodinase type I, selenoprotein, inducible by T3 (higher synthesis) and angiotensin II (positive chronotropic effect in myocard) Rattus sp.