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Literature summary extracted from

  • Shaw, L.; Schauer, R.
    Detection of CMP-N-acetylneuraminic acid hydroxylase activity in fractionated mouse liver (1989), Biochem. J., 263, 355-363.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.2 Co2+
-
 Mus musculus
1.14.18.2 Cu2+
-
 Mus musculus
1.14.18.2 EDTA
-
 Mus musculus
1.14.18.2 Mg2+
-
 Mus musculus
1.14.18.2 Mn2+
-
 Mus musculus
1.14.18.2 Ni2+
-
 Mus musculus
1.14.18.2 Zn2+
-
 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.18.2 additional information
-
 additional information
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.2 CMP-N-acetylneuraminate + NADH + O2 Mus musculus
-
 CMP-N-glycoloylneuraminate + NAD+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.2 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.2 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.2 CMP-N-acetylneuraminate + ascorbic acid + O2 ascorbate is ineffective Mus musculus CMP-N-glycoloylneuraminate + dehydroascorbate + H2O
-
 ?
1.14.18.2 CMP-N-acetylneuraminate + NADH + O2
-
 Mus musculus CMP-N-glycoloylneuraminate + NAD+ + H2O
-
 ?
1.14.18.2 CMP-N-acetylneuraminate + NADPH + O2
-
 Mus musculus CMP-N-glycoloylneuraminate + NADP+ + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.18.2 NADH
-
 Mus musculus
1.14.18.2 NADPH
-
 Mus musculus