EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.86 | 2-Hydroxyisovalerate | noncompetitive | Salmonella enterica subsp. enterica serovar Typhimurium | |
1.1.1.86 | NADP+ | linear non-competitive with respect to 2-acetolactate, linear competitive inhibitor of NADPH | Salmonella enterica subsp. enterica serovar Typhimurium |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.86 | Mg2+ | required | Salmonella enterica subsp. enterica serovar Typhimurium |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.86 | 2-acetolactate + NADPH | Salmonella enterica subsp. enterica serovar Typhimurium | enzyme of branched chain amino acid synthesis | 2,3-dihydroxy-3-methylbutanoate + NADP+ | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.86 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.86 | 2-acetolactate + NADPH | enzyme of branched chain amino acid synthesis | Salmonella enterica subsp. enterica serovar Typhimurium | 2,3-dihydroxy-3-methylbutanoate + NADP+ | - |
r | |
1.1.1.86 | NADPH + 2-acetolactate | ordered reaction with NADPH and the acetohydroxy acid adding in that order, and dihydroxy acid released before NADP+. 4 mol of NADPH bind per mol of enzyme | Salmonella enterica subsp. enterica serovar Typhimurium | NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.86 | NADPH | 4 mol of NADPH bind per mol of enzyme | Salmonella enterica subsp. enterica serovar Typhimurium |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.86 | additional information | - |
additional information | - |
Salmonella enterica subsp. enterica serovar Typhimurium |