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Literature summary extracted from

  • Lahteenmaki, K.; Kuusela, P.; Korhonen, T.K.
    Bacterial plasminogen activators and receptors (2001), FEMS Microbiol. Rev., 25, 531-552.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.48 PAI-1 inhibition of tissue-type plasminogen activator and urokinase Mammalia
3.4.23.48 PAI-2 inhibition of urokinase Mammalia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.23.48 plasminogen + H2O Mammalia activates plasminogen by cleaving the Arg560-Val561 bond plasmin + ?
-
 ?
3.4.23.48 plasminogen + H2O Yersinia pestis activates plasminogen by cleaving the Arg560-Val561 bond plasmin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.48 Mammalia
-
 tissue-type plasminogen activator and urokinase
-
3.4.23.48 Mycobacterium tuberculosis
-
-
-
3.4.23.48 Streptococcus uberis
-
 mechanism of plasminogen activation is not known
-
3.4.23.48 Yersinia pestis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.48 plasminogen + H2O activates plasminogen by cleaving the Arg560-Val561 bond Mammalia plasmin + ?
-
 ?
3.4.23.48 plasminogen + H2O activates plasminogen by cleaving the Arg560-Val561 bond Yersinia pestis plasmin + ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.23.48 additional information Pla occurs in 3 processed forms of alpha-Pla, beta-Pla and gamma-Pla, of which alpha-Pla with an apparant molecular mass of 37000 Da, corresponds to full-size mature Pla, and beta-Pla and gamma-Pla with molecular weights of 31000 Da and 35000 Da respectively, are thought to result from processing of alpha-Pla, beta-Pla may result from an autoprocessing event Yersinia pestis