Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Cambron, L.D.; Leskawa, K.C.
    Inhibition of CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase by nucleotides, nucleotide sugars and nucleotide dialdehydes (1993), Biochem. Biophys. Res. Commun., 193, 585-590.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.3.9 CMP
-
 Gallus gallus
2.4.3.9 CMPdialdehyde kinetics Gallus gallus
2.4.3.9 UDP
-
 Gallus gallus
2.4.3.9 UDP-N-acetylgalactosamine weak Gallus gallus
2.4.3.9 UDPdialdehyde kinetics Gallus gallus
2.4.3.9 UDPgalactose weak Gallus gallus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.3.9 0.0815
-
 lactosylceramide
-
 Gallus gallus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.3.9 microsome
-
 Gallus gallus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.3.9 CMP-N-acetylneuraminate + lactosylceramide Gallus gallus synthesizes the first ganglioside of the gangliotetraose series, GM3 CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.9 Gallus gallus
-
 15 days old embryo
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.9 brain
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.9 CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 Gallus gallus CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide i.e. ganglioside GM3 ?
2.4.3.9 CMP-N-acetylneuraminate + lactosylceramide synthesizes the first ganglioside of the gangliotetraose series, GM3 Gallus gallus CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.3.9 0.0853
-
 CMP-dialdehyde at 0.1 mM Gallus gallus
2.4.3.9 0.104
-
 CMP-dialdehyde at 0.2 mM Gallus gallus
2.4.3.9 0.219
-
 UDP-dialdehyde at 0.2 mM Gallus gallus