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Literature summary extracted from

  • O'Gara, J.P.; Dunican, L.K.
    Mutations in the trpD gene of Corynebacterium glutamicum confer 5-methyltryptophan resistance by encoding a feedback-resistant anthranilate phosphoribosyltransferase (1995), Appl. Environ. Microbiol., 61, 4477-4479.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.18
-
 Corynebacterium glutamicum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.18 5-Methyltryptophan 0.32 mM Corynebacterium glutamicum
2.4.2.18 L-tryptophan 0.83 mM Corynebacterium glutamicum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Corynebacterium glutamicum enzyme of tryptophan biosynthesis N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.18 Corynebacterium glutamicum
-
 wild-type and 5-methyltryptophan resistant mutant
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.2.18 0.049
-
 wild-type, crude extract Corynebacterium glutamicum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Corynebacterium glutamicum N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate enzyme of tryptophan biosynthesis Corynebacterium glutamicum N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?