EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.4.2.4 | - |
Escherichia coli |
2.4.2.4 | - |
Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.2.4 | 1-(8-phosphonooctyl)-6-amino-5-bromouracil | competitive | Homo sapiens | |
2.4.2.4 | 1-(8-phosphonooctyl)-7-deazaxanthine | competitive | Homo sapiens | |
2.4.2.4 | 5-bromo-6-aminouracil | - |
Homo sapiens | |
2.4.2.4 | 5-chloro-6-[1-(imminopyrrolidinyl)methyl]uracil hydrochloride | i.e. TPI, competitive | Homo sapiens | |
2.4.2.4 | 6-(4-phenlybutylamino)uracil | PBAU, 50% inhibition at 0.03 mM | Homo sapiens | |
2.4.2.4 | 6-aminothymine | - |
Homo sapiens | |
2.4.2.4 | 7-deazaxanthine | competitive, 50% inhibition at 0.04 mM | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.4.2.4 | 45000 | - |
2 * 45000 | Homo sapiens |
2.4.2.4 | 90000 | - |
- |
Escherichia coli |
2.4.2.4 | 90000 | - |
- |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.4 | additional information | Homo sapiens | role in thymidine metabolism, homeostasis, development and regeneration of central nervous system and formation of blood/brain barrier | ? | - |
? | |
2.4.2.4 | additional information | Homo sapiens | angiogenic activity | ? | - |
? | |
2.4.2.4 | thymine + 2-deoxy-D-ribose 1-phosphate | Escherichia coli | - |
thymidine + phosphate | - |
? | |
2.4.2.4 | thymine + 2-deoxy-D-ribose 1-phosphate | Homo sapiens | enzyme is enantioselective, acts only on the naturally occurring D-thymidine and some D-thymidine analogs, but not on their L-counterparts | thymidine + phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.2.4 | Escherichia coli | - |
- |
- |
2.4.2.4 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.4.2.4 | homogeneity | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.2.4 | blood platelet | - |
Homo sapiens | - |
2.4.2.4 | breast | tumor specimen | Homo sapiens | - |
2.4.2.4 | colonic cancer cell | - |
Homo sapiens | - |
2.4.2.4 | gastrointestinal cancer cell | - |
Homo sapiens | - |
2.4.2.4 | lung cancer cell | - |
Homo sapiens | - |
2.4.2.4 | macrophage | - |
Homo sapiens | - |
2.4.2.4 | additional information | no activity in normal brain | Homo sapiens | - |
2.4.2.4 | ovarian cancer cell | malignant tissue | Homo sapiens | - |
2.4.2.4 | pancreatic cancer cell | - |
Homo sapiens | - |
2.4.2.4 | renal cell carcinoma cell | - |
Homo sapiens | - |
2.4.2.4 | stomach | ulcer | Homo sapiens | - |
2.4.2.4 | uterus | leiomyoma | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.4 | 1-(tetrahydro-2-furanyl)-5-fluorouracil + phosphate | i.e. Tegafur | Homo sapiens | ? | - |
? | |
2.4.2.4 | 5'-deoxy-5-fluorouridine + phosphate | - |
Homo sapiens | 5-fluorouracil + 5-deoxyribose-1-phosphate | - |
? | |
2.4.2.4 | additional information | role in thymidine metabolism, homeostasis, development and regeneration of central nervous system and formation of blood/brain barrier | Homo sapiens | ? | - |
? | |
2.4.2.4 | additional information | angiogenic activity | Homo sapiens | ? | - |
? | |
2.4.2.4 | thymidine + phosphate | - |
Escherichia coli | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? | |
2.4.2.4 | thymidine + phosphate | enzyme is enantioselective, acts only on the naturally occurring D-thymidine and some D-thymidine analogs, but not on their L-counterparts | Homo sapiens | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? | |
2.4.2.4 | thymine + 2-deoxy-D-ribose 1-phosphate | - |
Escherichia coli | thymidine + phosphate | - |
? | |
2.4.2.4 | thymine + 2-deoxy-D-ribose 1-phosphate | enzyme is enantioselective, acts only on the naturally occurring D-thymidine and some D-thymidine analogs, but not on their L-counterparts | Homo sapiens | thymidine + phosphate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.4.2.4 | dimer | - |
Escherichia coli |
2.4.2.4 | dimer | 2 * 45000 | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.2.4 | 0.00002 | - |
5-chloro-6-[1-(imminopyrrolidinyl)methyl]uracil hydrochloride | - |
Homo sapiens |