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Literature summary extracted from

  • Wolff, E.C.; Folk, J.E.; Park, M.H.
    Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase (1997), J. Biol. Chem., 272, 15865-15871.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.46 1-amino-7-guanidinoheptane competitive, inhibits binding of spermidine to the enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.46 [eIF5A-precursor]-lysine + spermidine Homo sapiens first step in the biosynthesis of hypusine [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.46 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.46 [eIF5A-precursor]-lysine + spermidine
-
 Homo sapiens [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine i.e. [eIF5A-precursor]-N6-(4-aminobutyl)lysine ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine first step in the biosynthesis of hypusine Homo sapiens [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.5.1.46 NAD+
-
 Homo sapiens
2.5.1.46 NADH
-
 Homo sapiens