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Literature summary extracted from

  • Taguchi, H.; Iwai, K.
    Properties of the crystalline quinolinate phosphoribosyltransferase from hog liver (1975), Agric. Biol. Chem., 39, 1599-1604.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.19 Ag+ 1 mM, complete inhibition Sus scrofa
2.4.2.19 Al3+ 1 mM, 82.8% inhibition Sus scrofa
2.4.2.19 Ba2+ 1 mM, 38.1% inhibition Sus scrofa
2.4.2.19 Ca2+ 1 mM, 34.9% inhibition Sus scrofa
2.4.2.19 Cd2+ 1 mM, 75.5% inhibition Sus scrofa
2.4.2.19 Co2+ 1 mM, 65.2% inhibition Sus scrofa
2.4.2.19 Cr3+ 1 mM, 46.4% inhibition Sus scrofa
2.4.2.19 Cu2+ 1 mM, 86.9% inhibition Sus scrofa
2.4.2.19 Fe2+ 1 mM, 61.5% inhibition Sus scrofa
2.4.2.19 Fe3+ 1 mM, 92.9% inhibition Sus scrofa
2.4.2.19 Hg2+ 1 mM, 99.9% inhibition Sus scrofa
2.4.2.19 Mg2+ 1 mM, 7.7% inhibition Sus scrofa
2.4.2.19 Mn2+ 1 mM, 80.3% inhibition Sus scrofa
2.4.2.19 Ni2+ 1 mM, 76.5% inhibition Sus scrofa
2.4.2.19 Sr2+ 47.6% inhibition Sus scrofa
2.4.2.19 Zn2+ 1 mM, 82.1% inhibition Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.19 0.12
-
 quinolinate
-
 Sus scrofa
2.4.2.19 0.18
-
 5-phospho-alpha-D-ribose 1-diphosphate
-
 Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.19 Cd2+ can partially replace Mg2+ Sus scrofa
2.4.2.19 Co2+ can partially replace Mg2+ Sus scrofa
2.4.2.19 Mg2+ divalent cation required, Mg2+ is most effective at 1 mM Sus scrofa
2.4.2.19 Zn2+ can partially replace Mg2+ Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.19 additional information Sus scrofa intermediary enzyme in the de novo NAD biosynthetic pathway ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.19 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.19 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.19 additional information intermediary enzyme in the de novo NAD biosynthetic pathway Sus scrofa ?
-
 ?
2.4.2.19 pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Sus scrofa nicotinate D-ribonucleotide + diphosphate + CO2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.19 6.1
-
-
 Sus scrofa

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.4.2.19 5.2 7.8 half maximal activity at pH 5.2 and pH 7.8 Sus scrofa