EC Number | Application | Comment | Organism |
---|---|---|---|
2.5.1.58 | medicine | - |
Rattus norvegicus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.58 | Mg2+ | the magnesium affinity of enzyme increases with pH with a pka of 7.4, presumably reflecting the deprotonation of the farnesyl diphosphate to enhance magnesium coordination | Rattus norvegicus | |
2.5.1.58 | Mg2+ | appears to coordinate the diphosphate moiety of farnesyl diphosphate | Rattus norvegicus | |
2.5.1.58 | additional information | a metal-assisted nucleophile is involved in the catalytic mechanism of enzyme | Rattus norvegicus | |
2.5.1.58 | Zn2+ | required | Rattus norvegicus | |
2.5.1.58 | Zn2+ | zinc metalloenzyme | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.58 | farnesyl diphosphate + protein-cysteine | Rattus norvegicus | process necessary for the subcellular localisation of substrate to the plasma membrane | S-farnesyl protein + diphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.58 | Rattus norvegicus | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.5.1.58 | farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate | kinetic mechanism | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.58 | farnesyl diphosphate + protein-cysteine | prenylation, farnesylation, substrates are Ras, nuclear lamins, transducin gamma subunit, protein substrate motif: Cys-aliphatic-aliphatic-X, X: M, S, Q, A, F | Rattus norvegicus | diphosphate + S-farnesyl protein | - |
? | |
2.5.1.58 | farnesyl diphosphate + protein-cysteine | process necessary for the subcellular localisation of substrate to the plasma membrane | Rattus norvegicus | S-farnesyl protein + diphosphate | - |
? | |
2.5.1.58 | farnesyl monophosphate + Gly-Cys-Val-Leu-Ser | - |
Rattus norvegicus | phosphate + Gly-S-farnesyl-Cys-Val-Leu-Ser | - |
? |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.5.1.58 | additional information | - |
additional information | - |
Rattus norvegicus |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
2.5.1.58 | additional information | - |
pH-dependence of the chemical step of product formation: the reaction is characterized by two ionizations, drastic differences in the pH dependence of farnesyl diphophate and farnesyl monophosphate, the magnesium affinity of enzyme increases with pH with a pka of 7.4 | Rattus norvegicus |