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Literature summary extracted from

  • Bureau, V.; Marionneau, S.; Cailleau-Thomas, A.; Le Moullac-Vaidye, B.; Liehr, T.; Le Pendu, J.
    Comparison of the three rat GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferases FTA, FTB and FTC (2001), Eur. J. Biochem., 268, 1006-1019.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.69 cloning of gene FTB and FTC Rattus norvegicus
2.4.1.69 transfection of Chinese hamster ovary cells Rattus norvegicus
2.4.1.344 transfection of Chinese hamster ovary cells Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.69 0.024
-
 GDP-L-fucose enzyme FTB Rattus norvegicus
2.4.1.69 0.024
-
 GDP-beta-L-fucose pH 7.2, 37°C Rattus norvegicus
2.4.1.69 0.068
-
 GDP-L-fucose enzyme FTA Rattus norvegicus
2.4.1.69 0.068
-
 GDP-beta-L-fucose pH 7.2, 37°C Rattus norvegicus
2.4.1.69 3.8
-
 galacto-N-biose enzyme FTB Rattus norvegicus
2.4.1.69 3.8
-
 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine pH 7.2, 37°C Rattus norvegicus
2.4.1.69 5.2
-
 N-acetyllactosamine enzyme FTA Rattus norvegicus
2.4.1.69 7.1
-
 lacto-N-biose enzyme FTA Rattus norvegicus
2.4.1.69 7.1
-
 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine pH 7.2, 37°C Rattus norvegicus
2.4.1.69 8.3
-
 lacto-N-biose enzyme FTB Rattus norvegicus
2.4.1.69 8.3
-
 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine pH 7.2, 37°C Rattus norvegicus
2.4.1.69 11.1
-
 galacto-N-biose enzyme FTA Rattus norvegicus
2.4.1.69 11.1
-
 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine pH 7.2, 37°C Rattus norvegicus
2.4.1.69 20
-
 N-acetyllactosamine enzyme FTB Rattus norvegicus
2.4.1.69 25
-
 phenyl beta-galactose enzyme FTB Rattus norvegicus
2.4.1.69 25
-
 phenyl beta-galactose enzyme FTA Rattus norvegicus
2.4.1.69 33
-
 phenyl beta-D-galactopyranoside pH 7.2, 37°C Rattus norvegicus
2.4.1.344 0.024
-
 GDP-beta-L-fucose pH 7.2, 37°C Rattus norvegicus
2.4.1.344 0.068
-
 GDP-beta-L-fucose pH 7.2, 37°C Rattus norvegicus
2.4.1.344 5.2
-
 beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine pH 7.2, 37°C Rattus norvegicus
2.4.1.344 20
-
 beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine pH 7.2, 37°C Rattus norvegicus
2.4.1.344 25
-
 phenyl beta-D-galactopyranoside pH 7.2, 37°C Rattus norvegicus
2.4.1.344 33
-
 phenyl beta-D-galactopyranoside pH 7.2, 37°C Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.69 GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine Rattus norvegicus residues of H type 3 epitopes, reaction of EC 2.4.1.69 GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine
-
 ?
2.4.1.69 GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine Rattus norvegicus residues of H type 1 epitopes, reaction of EC 2.4.1.69 GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine
-
 ?
2.4.1.69 GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-galactosamine Rattus norvegicus residues of H type 3 epitopes, reaction of EC 2.4.1.69 GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-galactosamine
-
 ?
2.4.1.69 GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine Rattus norvegicus residues of H type 2 epitopes GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
 ?
2.4.1.69 GDP-beta-L-fucose + phenyl beta-D-galactopyranoside Rattus norvegicus
-
 GDP + phenyl alpha-L-fucosyl-(1->2)-beta-D-galactopyranoside
-
 ?
2.4.1.344 GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine Rattus norvegicus residues of H type 3 epitopes, reaction of EC 2.4.1.69 GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine
-
 ?
2.4.1.344 GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine Rattus norvegicus residues of H type 1 epitopes, reaction of EC 2.4.1.69 GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine
-
 ?
2.4.1.344 GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-galactosamine Rattus norvegicus residues of H type 3 epitopes, reaction of EC 2.4.1.69 GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-galactosamine
-
 ?
2.4.1.344 GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine Rattus norvegicus residues of H type 2 epitopes GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
 ?
2.4.1.344 GDP-beta-L-fucose + phenyl beta-D-galactopyranoside Rattus norvegicus
-
 GDP + phenyl alpha-L-fucosyl-(1->2)-beta-D-galactopyranoside
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.69 Rattus norvegicus
-
 three alpha1,2-fucosyltransferase genes: FTA, FTB and FTC
-
2.4.1.69 Rattus norvegicus Q10980
-
-
2.4.1.69 Rattus norvegicus Q10984
-
-
2.4.1.344 Rattus norvegicus Q10980
-
-
2.4.1.344 Rattus norvegicus Q10984
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.69 distal colon mRNA of FTA and FTC Rattus norvegicus
-
2.4.1.69 intestine small and large intestine Rattus norvegicus
-
2.4.1.69 intestine small and large intestines Rattus norvegicus
-
2.4.1.69 kidney mRNA of FTA and FTC Rattus norvegicus
-
2.4.1.69 liver mRNA of FTA and FTC Rattus norvegicus
-
2.4.1.69 lung mRNA of FTA and FTC Rattus norvegicus
-
2.4.1.69 lymph node mRNA of FTA and FTC Rattus norvegicus
-
2.4.1.69 additional information no cDNA detected in urinary bladder, the testis, the seminal vesicle, the ovary, the uterus, the spleen, the brain or muscle Rattus norvegicus
-
2.4.1.69 olfactory bulb
-
 Rattus norvegicus
-
2.4.1.69 proximal colon mRNA of FTA, FTB and FTC Rattus norvegicus
-
2.4.1.69 salivary gland
-
 Rattus norvegicus
-
2.4.1.69 skin
-
 Rattus norvegicus
-
2.4.1.69 small intestine mRNA of FTA, FTB and FTC Rattus norvegicus
-
2.4.1.69 stomach
-
 Rattus norvegicus
-
2.4.1.69 submaxillary gland FTA mRNA and FTC mRNA Rattus norvegicus
-
2.4.1.344 intestine small and large intestine Rattus norvegicus
-
2.4.1.344 intestine small and large intestines Rattus norvegicus
-
2.4.1.344 additional information no cDNA detected in urinary bladder, the testis, the seminal vesicle, the ovary, the uterus, the spleen, the brain or muscle Rattus norvegicus
-
2.4.1.344 olfactory bulb
-
 Rattus norvegicus
-
2.4.1.344 salivary gland
-
 Rattus norvegicus
-
2.4.1.344 skin
-
 Rattus norvegicus
-
2.4.1.344 stomach
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.69 GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine residues of H type 3 epitopes, reaction of EC 2.4.1.69 Rattus norvegicus GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine
-
 ?
2.4.1.69 GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine residues of H type 3 epitopes Rattus norvegicus GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine
-
 ?
2.4.1.69 GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine residues of H type 1 epitopes, reaction of EC 2.4.1.69 Rattus norvegicus GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine
-
 ?
2.4.1.69 GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine residues of H type 1 epitopes Rattus norvegicus GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine
-
 ?
2.4.1.69 GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-galactosamine residues of H type 3 epitopes, reaction of EC 2.4.1.69 Rattus norvegicus GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-galactosamine
-
 ?
2.4.1.69 GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine residues of H type 2 epitopes Rattus norvegicus GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
 ?
2.4.1.69 GDP-beta-L-fucose + lacto-N-biose
-
 Rattus norvegicus ?
-
 ?
2.4.1.69 GDP-beta-L-fucose + phenyl beta-D-galactopyranoside
-
 Rattus norvegicus GDP + phenyl alpha-L-fucosyl-(1->2)-beta-D-galactopyranoside
-
 ?
2.4.1.69 GDP-L-fucose + beta-D-galactosyl-R
-
 Rattus norvegicus GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
 ?
2.4.1.69 GDP-L-fucose + galacto-N-biose
-
 Rattus norvegicus GDP + alpha-L-fucosyl-1,2-galacto-N-biose
-
 ?
2.4.1.69 GDP-L-fucose + lacto-N-biose 1
-
 Rattus norvegicus GDP + L-Fucalpha(1-2)Galbeta(1-3)GlcNAc
-
 ?
2.4.1.69 GDP-L-fucose + N-acetyllactosamine
-
 Rattus norvegicus GDP + alpha-L-fucosyl-1,2-N-acetyllactosamine
-
 ?
2.4.1.69 GDP-L-fucose + phenyl-beta-D-galactoside
-
 Rattus norvegicus GDP + phenyl 2-O-(alpha-L-fucopyranosyl)-beta-D-galactopyranoside
-
 ?
2.4.1.344 GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine residues of H type 3 epitopes, reaction of EC 2.4.1.69 Rattus norvegicus GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine
-
 ?
2.4.1.344 GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine residues of H type 1 epitopes, reaction of EC 2.4.1.69 Rattus norvegicus GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine
-
 ?
2.4.1.344 GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-galactosamine residues of H type 3 epitopes, reaction of EC 2.4.1.69 Rattus norvegicus GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-galactosamine
-
 ?
2.4.1.344 GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine residues of H type 2 epitopes Rattus norvegicus GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
 ?
2.4.1.344 GDP-beta-L-fucose + phenyl beta-D-galactopyranoside
-
 Rattus norvegicus GDP + phenyl alpha-L-fucosyl-(1->2)-beta-D-galactopyranoside
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.69 FTA
-
 Rattus norvegicus
2.4.1.69 Ftb
-
 Rattus norvegicus
2.4.1.69 FUT1
-
 Rattus norvegicus
2.4.1.69 FUT2
-
 Rattus norvegicus
2.4.1.69 galactoside 2-alpha-L-fucosyltransferase 1
-
 Rattus norvegicus
2.4.1.69 galactoside 2-alpha-L-fucosyltransferase 2
-
 Rattus norvegicus
2.4.1.344 FTA
-
 Rattus norvegicus
2.4.1.344 Ftb
-
 Rattus norvegicus
2.4.1.344 FUT1
-
 Rattus norvegicus
2.4.1.344 FUT2
-
 Rattus norvegicus
2.4.1.344 galactoside 2-alpha-L-fucosyltransferase 1
-
 Rattus norvegicus
2.4.1.344 galactoside 2-alpha-L-fucosyltransferase 2
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
2.4.1.69 physiological function isoform Fta allows synthesis of H type 2 and H type 3 histo-blood group antigen epitopes at the cell surface. In Chinese hamster ovary cells transfected by FTA, FTA is able to synthesize H type 2 epitopes on a large set of glycoproteins Rattus norvegicus
2.4.1.344 physiological function isoform Fta allows synthesis of H type 2 and H type 3 histo-blood group antigen epitopes at the cell surface. In Chinese hamster ovary cells transfected by FTA, FTA is able to synthesize H type 2 epitopes on a large set of glycoproteins Rattus norvegicus