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Literature summary extracted from

  • Domino, S.E.; Hiraiwa, N.; Lowe, J.B.
    Molecular cloning, chromosomal assignment and tissue-specific expression of a murine alpha-(1,2)fucosyltransferase expressed in thymic and epididymal epithelial cells (1997), Biochem. J., 327, 105-115.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.69 expression in COS-7 cells Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.69 0.016
-
 GDP-L-fucose reaction with GM1, recombinant enzyme Mus musculus
2.4.1.69 0.052
-
 lactosylceramide recombinant enzyme Mus musculus
2.4.1.69 0.068
-
 lactosylceramide
-
 Mus musculus
2.4.1.69 0.068
-
 lactosylceramide recombinant enzyme Homo sapiens
2.4.1.69 0.07
-
 GDP-L-fucose reaction with GM1, recombinant enzyme Homo sapiens
2.4.1.69 0.079
-
 GDP-L-fucose reaction with phenyl-beta-D-galactoside, recombinant enzyme Mus musculus
2.4.1.69 0.082
-
 GM1 recombinant enzyme Homo sapiens
2.4.1.69 0.11
-
 GM1 recombinant enzyme Mus musculus
2.4.1.69 5.6
-
 lacto-N-biose recombinant enzyme Mus musculus
2.4.1.69 7.6
-
 phenyl-beta-D-galactoside recombinant enzyme Mus musculus
2.4.1.69 8.9
-
 lactose
-
 Homo sapiens
2.4.1.69 8.9
-
 lactose recombinant enzyme Mus musculus
2.4.1.69 14.3
-
 N-acetyl-beta-lactosamine recombinant enzyme Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.69 GDP-L-fucose + beta-D-galactosyl-R Homo sapiens
-
 GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
 ?
2.4.1.69 GDP-L-fucose + beta-D-galactosyl-R Mus musculus the galactoside 2-alpha-L-fucosyltransferase gene determines the expression of terminal L-Fucalpha(1-2)Galbeta epitopes GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.69 Homo sapiens
-
-
-
2.4.1.69 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.69 colon
-
 Mus musculus
-
2.4.1.69 epididymis
-
 Mus musculus
-
2.4.1.69 lung
-
 Mus musculus
-
2.4.1.69 pancreas
-
 Mus musculus
-
2.4.1.69 small intestine
-
 Mus musculus
-
2.4.1.69 stomach
-
 Mus musculus
-
2.4.1.69 thymus
-
 Mus musculus
-
2.4.1.69 uterus
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.69 GDP-beta-L-fucose + lacto-N-biose
-
 Mus musculus ?
-
 ?
2.4.1.69 GDP-beta-L-fucose + lactosylceramide
-
 Homo sapiens ?
-
 ?
2.4.1.69 GDP-L-fucose + beta-D-galactosyl-R
-
 Mus musculus GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
 ?
2.4.1.69 GDP-L-fucose + beta-D-galactosyl-R
-
 Homo sapiens GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
 ?
2.4.1.69 GDP-L-fucose + beta-D-galactosyl-R the galactoside 2-alpha-L-fucosyltransferase gene determines the expression of terminal L-Fucalpha(1-2)Galbeta epitopes Mus musculus GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
 ?
2.4.1.69 GDP-L-fucose + GM1
-
 Mus musculus GDP + ?
-
 ?
2.4.1.69 GDP-L-fucose + GM1 ganglioside
-
 Homo sapiens GDP + ?
-
 ?
2.4.1.69 GDP-L-fucose + lacto-N-biose 1
-
 Mus musculus GDP + L-Fucalpha(1-2)Galbeta(1-3)GlcNAc
-
 ?
2.4.1.69 GDP-L-fucose + lacto-N-biose 1
-
 Homo sapiens GDP + L-Fucalpha(1-2)Galbeta(1-3)GlcNAc
-
 ?
2.4.1.69 GDP-L-fucose + lactose
-
 Mus musculus GDP + fucosyllactose
-
 ?
2.4.1.69 GDP-L-fucose + lactose
-
 Homo sapiens GDP + fucosyllactose
-
 ?
2.4.1.69 GDP-L-fucose + lactosylceramide
-
 Mus musculus GDP + ?
-
 ?
2.4.1.69 GDP-L-fucose + N-acetyllactosamine
-
 Mus musculus GDP + alpha-L-fucosyl-1,2-N-acetyllactosamine
-
 ?
2.4.1.69 GDP-L-fucose + N-acetyllactosamine
-
 Homo sapiens GDP + alpha-L-fucosyl-1,2-N-acetyllactosamine
-
 ?
2.4.1.69 GDP-L-fucose + phenyl-beta-D-galactoside
-
 Mus musculus GDP + phenyl 2-O-(alpha-L-fucopyranosyl)-beta-D-galactopyranoside
-
 ?
2.4.1.69 GDP-L-fucose + phenyl-beta-D-galactoside
-
 Homo sapiens GDP + phenyl 2-O-(alpha-L-fucopyranosyl)-beta-D-galactopyranoside
-
 ?