BRENDA - Enzyme Database

Selective inhibition of a plasma fucosyltransferase by N-ethylmaleimide

Chou, T.H.; Murphy, C.; Kessel, D.; Biochem. Biophys. Res. Commun. 74, 1001-1006 (1977)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.1.69
NEM
3 mM, inhibits H-gene specified enzyme
Homo sapiens
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.4.1.69
0.006
-
GDP-L-fucose
-
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.4.1.69
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.1.69
blood serum
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.1.69
GDP-L-fucose + beta-D-galactosyl-R
-
489352
Homo sapiens
GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
-
-
?
2.4.1.69
GDP-L-fucose + lactose
-
489352
Homo sapiens
GDP + fucosyllactose
-
-
-
?
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.4.1.69
6.8
8
-
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.1.69
NEM
3 mM, inhibits H-gene specified enzyme
Homo sapiens
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.4.1.69
0.006
-
GDP-L-fucose
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.1.69
blood serum
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.1.69
GDP-L-fucose + beta-D-galactosyl-R
-
489352
Homo sapiens
GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
-
-
?
2.4.1.69
GDP-L-fucose + lactose
-
489352
Homo sapiens
GDP + fucosyllactose
-
-
-
?
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.4.1.69
6.8
8
-
Homo sapiens