EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.16 | Nikkomycin | competitive; competitive inhibitor of chitin synthetase 2; nikkomycin X and nikkomycin Z; nikkomycin Z is more inhibitory to chitin synthetase 1 than for chitin synthetase 2 | Saccharomyces cerevisiae | |
2.4.1.16 | nikkomycin X | - |
Saccharomyces cerevisiae | |
2.4.1.16 | nikkomycin Z | - |
Saccharomyces cerevisiae | |
2.4.1.16 | Polyoxin D | competitive inhibitor of chitin synthetase 2; more inhibitory to chitin synthetase 1 than for chitin synthetase 2 | Saccharomyces cerevisiae |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.16 | UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n | Saccharomyces cerevisiae | chitin synthetase 2 is essential for primary septum formation, chitin synthetase 1 is a repair enzyme | UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.16 | Saccharomyces cerevisiae | - |
chitin synthetase 1 and 2 | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.16 | UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n | - |
Saccharomyces cerevisiae | UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1 | - |
? | |
2.4.1.16 | UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n | chitin synthetase 2 is essential for primary septum formation, chitin synthetase 1 is a repair enzyme | Saccharomyces cerevisiae | UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1 | - |
? |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.1.16 | 0.00014 | - |
nikkomycin X | chitin synthetase 1 | Saccharomyces cerevisiae | |
2.4.1.16 | 0.00025 | - |
nikkomycin Z | chitin synthetase 1 | Saccharomyces cerevisiae | |
2.4.1.16 | 0.0009 | - |
5-((2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl)amino)-1-(5-carboxy-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-1,5-dideoxy-beta-D-allofuranuronic acid | chitin synthetase 1 | Saccharomyces cerevisiae |