BRENDA - Enzyme Database

Transglutaminases: multifunctional cross-linking enzymes that stabilize tissues

Greenberg, C.S.; Birckbichler, P.J.; Rice, R.H.; FASEB J. 5, 3071-3077 (1991)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.3.2.13
thrombin
-
Mus musculus
2.3.2.13
thrombin
-
Rattus norvegicus
2.3.2.13
thrombin
-
Cavia porcellus
2.3.2.13
thrombin
-
Homo sapiens
Cloned(Commentary)
EC Number
Commentary
Organism
2.3.2.13
cloning of placenta FXIIIa-gene cDNA; factor XIII, transglutaminase C and transglutaminase K
Homo sapiens
2.3.2.13
liver transglutaminase C
Cavia porcellus
2.3.2.13
transglutaminase C from macrophage
Mus musculus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.2.13
GTP
inhibition of tissue transglutaminase
Cavia porcellus
2.3.2.13
GTP
inhibition of tissue transglutaminase
Mus musculus
2.3.2.13
GTP
inhibition of tissue transglutaminase
Rattus norvegicus
2.3.2.13
GTP
inhibition of tissue transglutaminase
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.2.13
cytoplasm
tissue transglutaminase, factor XIIIa
Cavia porcellus
5737
-
2.3.2.13
cytoplasm
tissue transglutaminase, factor XIIIa
Homo sapiens
5737
-
2.3.2.13
cytoplasm
tissue transglutaminase, factor XIIIa
Mus musculus
5737
-
2.3.2.13
cytoplasm
tissue transglutaminase, factor XIIIa
Rattus norvegicus
5737
-
2.3.2.13
membrane
keratocytes
Homo sapiens
16020
-
2.3.2.13
membrane
-
Rattus norvegicus
16020
-
2.3.2.13
particle-bound
on the surface of monocytes and tissue macrophages
Mus musculus
-
-
2.3.2.13
particle-bound
tissue transglutaminase of rat hepatocytes
Rattus norvegicus
-
-
2.3.2.13
particle-bound
-
Cavia porcellus
-
-
2.3.2.13
particle-bound
-
Homo sapiens
-
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.3.2.13
Ca2+
requirement
Rattus norvegicus
2.3.2.13
Ca2+
requirement
Mus musculus
2.3.2.13
Ca2+
requirement
Cavia porcellus
2.3.2.13
Ca2+
requirement
Homo sapiens
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.3.2.13
80000
-
alpha2beta2, 2 * 83005 + 2 * 80000, plasma factor XIII, deduced from amino acid sequence
Homo sapiens
2.3.2.13
83005
-
alpha2beta2, 2 * 83005 + 2 * 80000, plasma factor XIII, deduced from amino acid sequence
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.2.13
Cavia porcellus
-
-
-
2.3.2.13
Homo sapiens
-
-
-
2.3.2.13
Mus musculus
-
-
-
2.3.2.13
Rattus norvegicus
-
-
-
Posttranslational Modification
EC Number
Posttranslational Modification
Commentary
Organism
2.3.2.13
lipoprotein
membrane-bound enzyme of keratocytes is anchored via palmitate and myristate
Homo sapiens
2.3.2.13
additional information
no glycoprotein
Mus musculus
2.3.2.13
additional information
no glycoprotein
Rattus norvegicus
2.3.2.13
additional information
no glycoprotein
Cavia porcellus
2.3.2.13
additional information
no glycoprotein
Homo sapiens
Reaction
EC Number
Reaction
Commentary
Organism
2.3.2.13
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3
structure, function, evolution
Mus musculus
2.3.2.13
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3
structure, function, evolution
Rattus norvegicus
2.3.2.13
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3
structure, function, evolution
Cavia porcellus
2.3.2.13
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3
structure, function, evolution
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.2.13
endothelium
-
Homo sapiens
-
2.3.2.13
epidermis
-
Cavia porcellus
-
2.3.2.13
epidermis
callus, keratinocytes
Homo sapiens
-
2.3.2.13
epidermis
-
Mus musculus
-
2.3.2.13
hair follicle
-
Cavia porcellus
-
2.3.2.13
hair follicle
outer root shear cells
Homo sapiens
-
2.3.2.13
hair follicle
-
Mus musculus
-
2.3.2.13
hepatocyte
-
Rattus norvegicus
-
2.3.2.13
liver
-
Rattus norvegicus
-
2.3.2.13
liver
-
Homo sapiens
-
2.3.2.13
liver
-
Mus musculus
-
2.3.2.13
liver
-
Cavia porcellus
-
2.3.2.13
macrophage
-
Mus musculus
-
2.3.2.13
additional information
tissue distribution
Cavia porcellus
-
2.3.2.13
additional information
tissue distribution
Homo sapiens
-
2.3.2.13
additional information
tissue distribution
Mus musculus
-
2.3.2.13
additional information
tissue distribution
Rattus norvegicus
-
2.3.2.13
placenta
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.2.13
protein-bound gamma-glutamine + alkylamine
substrate fibronectin
487830
Cavia porcellus
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Cavia porcellus
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
substrate fibronectin
487830
Mus musculus
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Mus musculus
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
substrate fibronectin
487830
Homo sapiens
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Homo sapiens
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
substrate fibronectin
487830
Rattus norvegicus
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Rattus norvegicus
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
catalyzes post-translational protein modifications by transamidation of glutamine residues
487830
Cavia porcellus
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Cavia porcellus
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
catalyzes post-translational protein modifications by transamidation of glutamine residues
487830
Mus musculus
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Mus musculus
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
catalyzes post-translational protein modifications by transamidation of glutamine residues
487830
Homo sapiens
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Homo sapiens
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
catalyzes post-translational protein modifications by transamidation of glutamine residues
487830
Rattus norvegicus
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Rattus norvegicus
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
forms intramolecular isopeptide bonds between fibrin molecules
487830
Cavia porcellus
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Cavia porcellus
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
forms intramolecular isopeptide bonds between fibrin molecules
487830
Mus musculus
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Mus musculus
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
forms intramolecular isopeptide bonds between fibrin molecules
487830
Homo sapiens
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Homo sapiens
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
forms intramolecular isopeptide bonds between fibrin molecules
487830
Rattus norvegicus
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Rattus norvegicus
?
Subunits
EC Number
Subunits
Commentary
Organism
2.3.2.13
More
zymogens of plasma and platelet-coagulation factor XIIIa with different subunit structure: alpha2beta2 and alpha2, respectively
Homo sapiens
2.3.2.13
tetramer
alpha2beta2, 2 * 83005 + 2 * 80000, plasma factor XIII, deduced from amino acid sequence
Homo sapiens
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.3.2.13
thrombin
-
Mus musculus
2.3.2.13
thrombin
-
Rattus norvegicus
2.3.2.13
thrombin
-
Cavia porcellus
2.3.2.13
thrombin
-
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.3.2.13
cloning of placenta FXIIIa-gene cDNA; factor XIII, transglutaminase C and transglutaminase K
Homo sapiens
2.3.2.13
liver transglutaminase C
Cavia porcellus
2.3.2.13
transglutaminase C from macrophage
Mus musculus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.2.13
GTP
inhibition of tissue transglutaminase
Cavia porcellus
2.3.2.13
GTP
inhibition of tissue transglutaminase
Mus musculus
2.3.2.13
GTP
inhibition of tissue transglutaminase
Rattus norvegicus
2.3.2.13
GTP
inhibition of tissue transglutaminase
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.2.13
cytoplasm
tissue transglutaminase, factor XIIIa
Cavia porcellus
5737
-
2.3.2.13
cytoplasm
tissue transglutaminase, factor XIIIa
Homo sapiens
5737
-
2.3.2.13
cytoplasm
tissue transglutaminase, factor XIIIa
Mus musculus
5737
-
2.3.2.13
cytoplasm
tissue transglutaminase, factor XIIIa
Rattus norvegicus
5737
-
2.3.2.13
membrane
keratocytes
Homo sapiens
16020
-
2.3.2.13
membrane
-
Rattus norvegicus
16020
-
2.3.2.13
particle-bound
on the surface of monocytes and tissue macrophages
Mus musculus
-
-
2.3.2.13
particle-bound
tissue transglutaminase of rat hepatocytes
Rattus norvegicus
-
-
2.3.2.13
particle-bound
-
Cavia porcellus
-
-
2.3.2.13
particle-bound
-
Homo sapiens
-
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.3.2.13
Ca2+
requirement
Rattus norvegicus
2.3.2.13
Ca2+
requirement
Mus musculus
2.3.2.13
Ca2+
requirement
Cavia porcellus
2.3.2.13
Ca2+
requirement
Homo sapiens
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.3.2.13
80000
-
alpha2beta2, 2 * 83005 + 2 * 80000, plasma factor XIII, deduced from amino acid sequence
Homo sapiens
2.3.2.13
83005
-
alpha2beta2, 2 * 83005 + 2 * 80000, plasma factor XIII, deduced from amino acid sequence
Homo sapiens
Posttranslational Modification (protein specific)
EC Number
Posttranslational Modification
Commentary
Organism
2.3.2.13
lipoprotein
membrane-bound enzyme of keratocytes is anchored via palmitate and myristate
Homo sapiens
2.3.2.13
additional information
no glycoprotein
Mus musculus
2.3.2.13
additional information
no glycoprotein
Rattus norvegicus
2.3.2.13
additional information
no glycoprotein
Cavia porcellus
2.3.2.13
additional information
no glycoprotein
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.2.13
endothelium
-
Homo sapiens
-
2.3.2.13
epidermis
-
Cavia porcellus
-
2.3.2.13
epidermis
callus, keratinocytes
Homo sapiens
-
2.3.2.13
epidermis
-
Mus musculus
-
2.3.2.13
hair follicle
-
Cavia porcellus
-
2.3.2.13
hair follicle
outer root shear cells
Homo sapiens
-
2.3.2.13
hair follicle
-
Mus musculus
-
2.3.2.13
hepatocyte
-
Rattus norvegicus
-
2.3.2.13
liver
-
Rattus norvegicus
-
2.3.2.13
liver
-
Homo sapiens
-
2.3.2.13
liver
-
Mus musculus
-
2.3.2.13
liver
-
Cavia porcellus
-
2.3.2.13
macrophage
-
Mus musculus
-
2.3.2.13
additional information
tissue distribution
Cavia porcellus
-
2.3.2.13
additional information
tissue distribution
Homo sapiens
-
2.3.2.13
additional information
tissue distribution
Mus musculus
-
2.3.2.13
additional information
tissue distribution
Rattus norvegicus
-
2.3.2.13
placenta
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.2.13
protein-bound gamma-glutamine + alkylamine
substrate fibronectin
487830
Cavia porcellus
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Cavia porcellus
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
substrate fibronectin
487830
Mus musculus
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Mus musculus
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
substrate fibronectin
487830
Homo sapiens
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Homo sapiens
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
substrate fibronectin
487830
Rattus norvegicus
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Rattus norvegicus
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
catalyzes post-translational protein modifications by transamidation of glutamine residues
487830
Cavia porcellus
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Cavia porcellus
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
catalyzes post-translational protein modifications by transamidation of glutamine residues
487830
Mus musculus
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Mus musculus
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
catalyzes post-translational protein modifications by transamidation of glutamine residues
487830
Homo sapiens
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Homo sapiens
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
catalyzes post-translational protein modifications by transamidation of glutamine residues
487830
Rattus norvegicus
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Rattus norvegicus
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
forms intramolecular isopeptide bonds between fibrin molecules
487830
Cavia porcellus
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Cavia porcellus
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
forms intramolecular isopeptide bonds between fibrin molecules
487830
Mus musculus
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Mus musculus
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
forms intramolecular isopeptide bonds between fibrin molecules
487830
Homo sapiens
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Homo sapiens
?
2.3.2.13
protein-bound gamma-glutamine + alkylamine
forms intramolecular isopeptide bonds between fibrin molecules
487830
Rattus norvegicus
protein N5-alkylglutamine + NH3
resulting bonds are covalent and stable to proteolysis
487830
Rattus norvegicus
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
2.3.2.13
More
zymogens of plasma and platelet-coagulation factor XIIIa with different subunit structure: alpha2beta2 and alpha2, respectively
Homo sapiens
2.3.2.13
tetramer
alpha2beta2, 2 * 83005 + 2 * 80000, plasma factor XIII, deduced from amino acid sequence
Homo sapiens