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Literature summary extracted from

  • Bras, A.P.M.; Jänne, J.; Porter, C.W.; Sitar, D.S.
    Spermidine/spermine N1-acetyltransferase catalyzes amantadine acetylation (2001), Drug Metab. Dispos., 29, 676-680.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.57 transgenic CD2F1 mice overexpressing SSAT Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.57 amantadine competitively inhibits spermidine acetylation, at 10 mM: complete inhibition Mus musculus
2.3.1.57 additional information not inhibited by p-aminobenzoic acid Mus musculus
2.3.1.57 sulfamethazine inhibits spermidine acetylation Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.57 0.267
-
 spermidine
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.57 cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.57 acetyl-CoA + amantadine Mus musculus reaction occurs in vivo and in vitro, but only in presence of increased enzyme levels, amantadine may be a specific drug substrate for SSAT CoA + N1-acetylamantadine
-
 ?
2.3.1.57 additional information Mus musculus polyamine catabolic enzyme ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.57 Mus musculus
-
 transgenic male CD2F1 mice overexpressing SSAT
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.57 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.57 acetyl-CoA + amantadine reaction occurs in vivo and in vitro, but only in presence of increased enzyme levels, amantadine may be a specific drug substrate for SSAT Mus musculus CoA + N1-acetylamantadine
-
 ?
2.3.1.57 acetyl-CoA + spermidine
-
 Mus musculus CoA + N1-acetylspermidine
-
 ?
2.3.1.57 additional information polyamine catabolic enzyme Mus musculus ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.57 37
-
 assay at Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.57 0.738
-
 amantadine
-
 Mus musculus
2.3.1.57 3.5
-
 sulfamethazine
-
 Mus musculus