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Literature summary extracted from

  • Marshall, M.O.; Knudsen, J.
    The specificity of 1-acyl-sn-glycerol 3-phosphate acyltransferase in microsomal fractions from lactating cow mammary gland towards short, medium and long chain acyl-CoA esters (1977), Biochim. Biophys. Acta, 489, 236-241.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.51 additional information the enzyme can utilize the monomer form of long-chain acyl-CoA but it is inhibited by the micellar form of these substrates Bos taurus
2.3.1.51 stearoyl-CoA strongly inhibitory at 0.002 mM Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.51 microsome
-
 Bos taurus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.51 additional information Bos taurus 1-palmitoyl- and 1-oleoyl-sn-glycerol 3-phosphate are probably the substrates for the enzyme in vivo, since palmitic and oleic acids are the major fatty acid components at the sn-1 position of cow milk triacylglycerols. The specificity of the enzyme plays a major role in determining the fatty acid composition at the sn-2 position of cow milk triacylglycerols, though the influence of other factors such as the in vivo concentration of the acyl-CoAs and the specificities of the monoacylglycerol acyltransferases cannot be ruled out ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.51 Bos taurus
-
 Jersey cow
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.51 mammary gland lactating Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.51 acyl-CoA + 1-acyl-sn-glycerol 3-phosphate the enzyme is active towards acyl-CoAs of chain length C-8 to C-18 Bos taurus CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 acyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
 Bos taurus CoA + 2-acyl-1-oleoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 acyl-CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
 Bos taurus CoA + 1-palmitoyl-2-acyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 additional information no acyl-donors are butyryl-CoA and hexanoyl-CoA Bos taurus ?
-
 ?
2.3.1.51 additional information the chain length specificity of the enzyme in decreasing order is as follows: C16, C14, C12, C10, C8 Bos taurus ?
-
 ?
2.3.1.51 additional information 1-palmitoyl- and 1-oleoyl-sn-glycerol 3-phosphate are probably the substrates for the enzyme in vivo, since palmitic and oleic acids are the major fatty acid components at the sn-1 position of cow milk triacylglycerols. The specificity of the enzyme plays a major role in determining the fatty acid composition at the sn-2 position of cow milk triacylglycerols, though the influence of other factors such as the in vivo concentration of the acyl-CoAs and the specificities of the monoacylglycerol acyltransferases cannot be ruled out Bos taurus ?
-
 ?
2.3.1.51 palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate maximum activity is obtained with palmitoyl-CoA at a concentration of 0.002-0.003 mM Bos taurus CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.51 30
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.51 7.4
-
 assay at Bos taurus