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Literature summary extracted from

  • Van Echten-Deckert, G.; Zschoche, A.; Bar, T.; Schmidt, R.R.; Raths, A.; Heinemann, T.; Sandhoff, K.
    cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons (1997), J. Biol. Chem., 272, 15825-15833.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.50 cis-4-methylsphingosine time- and concentration-dependent, causes drastic morphological changes of the cells in vivo Mus musculus
2.3.1.50 cis-5-methylsphingosine weak inhibition Mus musculus
2.3.1.50 cis-sphingosine weak inhibition Mus musculus
2.3.1.50 trans-4-methylsphingosine
-
 Mus musculus
2.3.1.50 trans-5-methylsphingosine weak inhibition Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.50 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.50 cerebellum granule cells, neuronal cells Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.50 palmitoyl-CoA + L-serine
-
 Mus musculus CoA + 3-dehydro-D-sphinganine + CO2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.50 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.50 7.4
-
 assay at Mus musculus