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Literature summary extracted from

  • Weber, W.W.
    N-Acetyltransferase (mammalian liver) (1971), Methods Enzymol., 17B, 805-811.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.5 Cu2+
-
 Oryctolagus cuniculus
2.3.1.5 Cu2+
-
 Rattus norvegicus
2.3.1.5 Mn2+
-
 Oryctolagus cuniculus
2.3.1.5 additional information
-
 Homo sapiens
2.3.1.5 additional information no inhibition by CdCl2, arsenite, diisopropylfluorophosphate Oryctolagus cuniculus
2.3.1.5 additional information
-
 Platyrrhini
2.3.1.5 additional information
-
 Rattus norvegicus
2.3.1.5 N-ethylmaleimide
-
 Homo sapiens
2.3.1.5 N-ethylmaleimide
-
 Oryctolagus cuniculus
2.3.1.5 N-ethylmaleimide
-
 Platyrrhini
2.3.1.5 N-ethylmaleimide
-
 Rattus norvegicus
2.3.1.5 Ni2+
-
 Oryctolagus cuniculus
2.3.1.5 p-chloromercuribenzoate
-
 Oryctolagus cuniculus
2.3.1.5 Zn2+
-
 Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.5 0.02
-
 acetyl-CoA
-
 Oryctolagus cuniculus
2.3.1.5 0.18
-
 isoniazid
-
 Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.5 Homo sapiens
-
-
-
2.3.1.5 Oryctolagus cuniculus
-
 new Zealand white
-
2.3.1.5 Platyrrhini
-
-
-
2.3.1.5 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.5 acetyl-CoA + an arylamine = CoA + an N-acetylarylamine ping-pong bi-bi mechanism Homo sapiens
a
2.3.1.5 acetyl-CoA + an arylamine = CoA + an N-acetylarylamine ping-pong bi-bi mechanism Rattus norvegicus
a
2.3.1.5 acetyl-CoA + an arylamine = CoA + an N-acetylarylamine ping-pong bi-bi mechanism Oryctolagus cuniculus
a
2.3.1.5 acetyl-CoA + an arylamine = CoA + an N-acetylarylamine ping-pong bi-bi mechanism Platyrrhini
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.5 liver
-
 Homo sapiens
-
2.3.1.5 liver
-
 Rattus norvegicus
-
2.3.1.5 liver
-
 Oryctolagus cuniculus
-
2.3.1.5 liver
-
 Platyrrhini
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.5 0.16
-
-
 Oryctolagus cuniculus

Storage Stability

EC Number Storage Stability Organism
2.3.1.5 4°C, 20% loss of activity within 4 days in the presence of 1 mM EDTA Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.5 acetyl-CoA + 4-aminobenzoic acid
-
 Homo sapiens CoA + 4-acetylaminobenzoic acid
-
 ?
2.3.1.5 acetyl-CoA + 4-aminobenzoic acid
-
 Rattus norvegicus CoA + 4-acetylaminobenzoic acid
-
 ?
2.3.1.5 acetyl-CoA + 4-aminobenzoic acid
-
 Oryctolagus cuniculus CoA + 4-acetylaminobenzoic acid
-
 ?
2.3.1.5 acetyl-CoA + 4-aminosalicylic acid
-
 Homo sapiens CoA + 4-acetylamino-2-hydroxybenzoate
-
 ?
2.3.1.5 acetyl-CoA + 4-aminosalicylic acid
-
 Oryctolagus cuniculus CoA + 4-acetylamino-2-hydroxybenzoate
-
 ?
2.3.1.5 acetyl-CoA + aniline
-
 Oryctolagus cuniculus CoA + acetanilide
-
 ?
2.3.1.5 acetyl-CoA + diaminodiphenylsulfone
-
 Oryctolagus cuniculus CoA + ?
-
 ?
2.3.1.5 acetyl-CoA + histamine
-
 Rattus norvegicus CoA + N-acetylhistamine
-
 ?
2.3.1.5 acetyl-CoA + histamine
-
 Oryctolagus cuniculus CoA + N-acetylhistamine
-
 ?
2.3.1.5 acetyl-CoA + hydralazine
-
 Oryctolagus cuniculus CoA + ?
-
 ?
2.3.1.5 acetyl-CoA + isoniazide
-
 Homo sapiens CoA + acetylniazide
-
 ?
2.3.1.5 acetyl-CoA + isoniazide i.e. isonicotinyl hydrazide Oryctolagus cuniculus CoA + acetylniazide
-
 ?
2.3.1.5 acetyl-CoA + p-phenetidine
-
 Oryctolagus cuniculus CoA + N-(4-ethoxyphenyl)-acetamide
-
 ?
2.3.1.5 acetyl-CoA + serotonin
-
 Rattus norvegicus CoA + N-acetylserotonin
-
 ?
2.3.1.5 acetyl-CoA + serotonin
-
 Oryctolagus cuniculus CoA + N-acetylserotonin
-
 ?
2.3.1.5 acetyl-CoA + sulfadiazine
-
 Homo sapiens CoA + ?
-
 ?
2.3.1.5 acetyl-CoA + sulfadiazine
-
 Oryctolagus cuniculus CoA + ?
-
 ?
2.3.1.5 acetyl-CoA + sulfamerazine
-
 Homo sapiens CoA + ?
-
 ?
2.3.1.5 acetyl-CoA + sulfamerazine
-
 Oryctolagus cuniculus CoA + ?
-
 ?
2.3.1.5 acetyl-CoA + sulfamethazine
-
 Homo sapiens CoA + N-4-acetylsulfamethazine
-
 ?
2.3.1.5 acetyl-CoA + sulfamethazine
-
 Rattus norvegicus CoA + N-4-acetylsulfamethazine
-
 ?
2.3.1.5 acetyl-CoA + sulfamethazine
-
 Oryctolagus cuniculus CoA + N-4-acetylsulfamethazine
-
 ?
2.3.1.5 acetyl-CoA + sulfanilamide
-
 Oryctolagus cuniculus CoA + ?
-
 ?
2.3.1.5 additional information
-
 Homo sapiens ?
-
 ?
2.3.1.5 additional information
-
 Rattus norvegicus ?
-
 ?
2.3.1.5 additional information
-
 Platyrrhini ?
-
 ?
2.3.1.5 additional information N-diacetyl cysteamine can replace acetyl-CoA with less than 10% efficiency Oryctolagus cuniculus ?
-
 ?
2.3.1.5 additional information no substrate: phenylalanine, cyclohexylamine Oryctolagus cuniculus ?
-
 ?
2.3.1.5 additional information acetylthiocholine can replace acetyl-CoA Oryctolagus cuniculus ?
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.3.1.5 55
-
 inactivation after 2 min Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.5 5 9
-
 Oryctolagus cuniculus
2.3.1.5 5.7
-
-
 Rattus norvegicus
2.3.1.5 5.7
-
-
 Oryctolagus cuniculus
2.3.1.5 5.7
-
-
 Platyrrhini
2.3.1.5 5.7 7.4 sulfamethazine Oryctolagus cuniculus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.3.1.5 6.5
-
 irreversible inactivation below Oryctolagus cuniculus