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Literature summary extracted from

  • Mares, R.; Urbanowski, M.L.; Stauffer, G.V.
    Regulation of the Salmonella typhimurium metA gene by the metR protein and homocysteine (1992), J. Bacteriol., 174, 390-397.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.46 metA gene, expression in Escherichia coli auxotrophic strains as lacZ fusion proteins Salmonella enterica subsp. enterica serovar Typhimurium
2.3.1.46 metA gene, expression in Escherichia coli auxotrophic strains as lacZ fusion proteins Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.46 D-methionine slight feed-back inhibition Escherichia coli
2.3.1.46 D-methionine slight feed-back inhibition Salmonella enterica subsp. enterica serovar Typhimurium
2.3.1.46 L-methionine feed-back inhibition Escherichia coli
2.3.1.46 L-methionine feed-back inhibition Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.46 succinyl-CoA + L-homoserine Salmonella enterica subsp. enterica serovar Typhimurium
-
 CoA + O-succinyl-L-homoserine
-
 ?
2.3.1.46 succinyl-CoA + L-homoserine Escherichia coli involved in cystathionine and methionine biosynthesis CoA + O-succinyl-L-homoserine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.46 Escherichia coli
-
-
-
2.3.1.46 Escherichia coli
-
 metA gene
-
2.3.1.46 Escherichia coli
-
 auxotrophic mutants derived from K-12
-
2.3.1.46 Salmonella enterica subsp. enterica serovar Typhimurium
-
 metA gene
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.46 succinyl-CoA + L-homoserine
-
 Salmonella enterica subsp. enterica serovar Typhimurium CoA + O-succinyl-L-homoserine
-
 ?
2.3.1.46 succinyl-CoA + L-homoserine
-
 Escherichia coli CoA + O-succinyl-L-homoserine
-
 ?
2.3.1.46 succinyl-CoA + L-homoserine involved in cystathionine and methionine biosynthesis Escherichia coli CoA + O-succinyl-L-homoserine
-
 ?